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Waking Up in Pain: a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm

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Rasmussen, AM, Toft, MH, Awada, HN, Dirks, J, Brandsborg, B, Rasmussen, LK, Kirkegaard, E, Hasfeldt-Hansen, D, Larsen, TE, Charalampidis, G, Mørk, ELS, Rosager, CL, Salam, IA, Rasmussen, BS, Jørgensen, M, Skjønnemand, M, Lund, CA, Schroder, S, Sørensen, JK, Sølling, C, Hansen, KK, Rasmussen, CK, Steen, NP, Nielsen, AS, Geisler, A, Køppen, KS, Pælestik, MB, Grøfte, T, Meyhoff, CS, Kroh, CL, Christensen, AP, Haugstvedt, AF, Hansen, MA, Nielsen, CV, Dybdal, B, Falcon, L, Hägi-Pedersen, D, Jauho, K, Wolsted, H, Pedersen, CAK, Sommer, TN, Kromberg, LS, Kristensen, DL, Svensson, CK, Nielsen, HF, Sørensen, MK, Jacobsen, S, Sundskard, M, Brahe, N, Jakobsen, K, Jensen, MS, Odder, L, Selter, H, Mohr, TH, Jensen, EH, Jensen, PP, Skjold, C & Aasvang, EK 2021, 'Waking Up in Pain: a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm', Regional Anesthesia and Pain Medicine, bind 46, nr. 11, s. 948-953. https://doi.org/10.1136/rapm-2021-102583

APA

CBE

Rasmussen AM, Toft MH, Awada HN, Dirks J, Brandsborg B, Rasmussen LK, Kirkegaard E, Hasfeldt-Hansen D, Larsen TE, Charalampidis G, Mørk ELS, Rosager CL, Salam IA, Rasmussen BS, Jørgensen M, Skjønnemand M, Lund CA, Schroder S, Sørensen JK, Sølling C, Hansen KK, Rasmussen CK, Steen NP, Nielsen AS, Geisler A, Køppen KS, Pælestik MB, Grøfte T, Meyhoff CS, Kroh CL, Christensen AP, Haugstvedt AF, Hansen MA, Nielsen CV, Dybdal B, Falcon L, Hägi-Pedersen D, Jauho K, Wolsted H, Pedersen CAK, Sommer TN, Kromberg LS, Kristensen DL, Svensson CK, Nielsen HF, Sørensen MK, Jacobsen S, Sundskard M, Brahe N, Jakobsen K, Jensen MS, Odder L, Selter H, Mohr TH, Jensen EH, Jensen PP, Skjold C, Aasvang EK. 2021. Waking Up in Pain: a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm. Regional Anesthesia and Pain Medicine. 46(11):948-953. https://doi.org/10.1136/rapm-2021-102583

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Author

Rasmussen, Anders Mølgaard ; Toft, Mette Helene ; Awada, Hussein Nasser ; Dirks, Jesper ; Brandsborg, Birgitte ; Rasmussen, Line Kirkegaard ; Kirkegaard, Ellen ; Hasfeldt-Hansen, Dorthe ; Larsen, Thomas Egemose ; Charalampidis, Georgios ; Mørk, Emilie Louise Schjøtt ; Rosager, Chirstine Linaa ; Salam, Idress Ahmad ; Rasmussen, Bodil Steen ; Jørgensen, Marlene ; Skjønnemand, Martin ; Lund, Caterina Amanti ; Schroder, Save ; Sørensen, Johan Kløvgaard ; Sølling, Christoffer ; Hansen, Kristian Kraft ; Rasmussen, Christina Kirkegaard ; Steen, Nick Phaff ; Nielsen, Anne Staal ; Geisler, Anja ; Køppen, Kasper Storm ; Pælestik, Maria Bolther ; Grøfte, Thorbjørn ; Meyhoff, Christian Sylvest ; Kroh, Charlotte Loumann ; Christensen, Amalie Prien ; Haugstvedt, Aleksander Fjeld ; Hansen, Maria Aagaard ; Nielsen, Christian Viggo ; Dybdal, Bitten ; Falcon, Lars ; Hägi-Pedersen, Daniel ; Jauho, Kristian ; Wolsted, Henrik ; Pedersen, Christian Alves Kohler ; Sommer, Trine Nyboe ; Kromberg, Laurits Schou ; Kristensen, Danja Lykke ; Svensson, Camilla Kara ; Nielsen, Hans Fjeldsøe ; Sørensen, Martin Kryspin ; Jacobsen, Stig ; Sundskard, Martin ; Brahe, Nicole ; Jakobsen, Karina ; Jensen, Mette Skov ; Odder, Lillian ; Selter, Hansjörg ; Mohr, Tróndur Høgnason ; Jensen, Elin H ; Jensen, Pernille Pia ; Skjold, Christine ; Aasvang, Eske Kvanner. / Waking Up in Pain : a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm. I: Regional Anesthesia and Pain Medicine. 2021 ; Bind 46, Nr. 11. s. 948-953.

Bibtex

@article{a97ec970e2994a02bae66d27d0ea83f1,
title = "Waking Up in Pain: a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm",
abstract = "BACKGROUND: Acute and persistent pain after surgery is well described. However, no large-scale studies on immediate postoperative pain in the operating room (OR) exist, hindering potential areas of research to improve clinical outcomes. Thus, we aimed to describe the occurrence and severity of immediate postoperative pain in a large, unselected cohort.METHODS: This was a prospective cohort study, encompassing all procedures in 31 public hospitals in the Danish Realm, during a 5-day period including the weekend. Data on procedures and anesthesia were collected and the main outcome was occurrence of moderate or severe pain in the OR. Secondary outcomes included pain, sedation and nausea in the OR or during the first 15 min in the postanesthesia care unit (PACU) including relevant risk factors. Descriptive and logistic regression statistics were used.RESULTS: A total of 3675 procedures were included for analysis (87% inclusion rate). Moderate or severe pain occurred in 7.4% (95% CI 6.5% to 8.3%) of cases in the OR immediately after awakening, rising to 20.2% in the OR and/or PACU. Large intraprocedure and interprocedure variations occurred (0.0%-37.5%), and in 20% of cases with epidural-general anesthesia patients experienced moderate or severe pain. Independent risk factors were female sex, younger age, preoperative pain, daily opioid use and major surgical procedures.CONCLUSION: Moderate or severe pain in the immediate postoperative phase occurred in 20% of all cases with procedure and anesthesiological technique variations, suggesting a need for identification of relevant procedure-specific risk factors and development of preventive treatments.TRIAL REGISTRATION NUMBER: RoPR ID 43191.",
keywords = "Analgesics, Opioid, Anesthesia, General, Cohort Studies, Denmark/epidemiology, Female, Humans, Pain, Postoperative/diagnosis, Prospective Studies",
author = "Rasmussen, {Anders M{\o}lgaard} and Toft, {Mette Helene} and Awada, {Hussein Nasser} and Jesper Dirks and Birgitte Brandsborg and Rasmussen, {Line Kirkegaard} and Ellen Kirkegaard and Dorthe Hasfeldt-Hansen and Larsen, {Thomas Egemose} and Georgios Charalampidis and M{\o}rk, {Emilie Louise Schj{\o}tt} and Rosager, {Chirstine Linaa} and Salam, {Idress Ahmad} and Rasmussen, {Bodil Steen} and Marlene J{\o}rgensen and Martin Skj{\o}nnemand and Lund, {Caterina Amanti} and Save Schroder and S{\o}rensen, {Johan Kl{\o}vgaard} and Christoffer S{\o}lling and Hansen, {Kristian Kraft} and Rasmussen, {Christina Kirkegaard} and Steen, {Nick Phaff} and Nielsen, {Anne Staal} and Anja Geisler and K{\o}ppen, {Kasper Storm} and P{\ae}lestik, {Maria Bolther} and Thorbj{\o}rn Gr{\o}fte and Meyhoff, {Christian Sylvest} and Kroh, {Charlotte Loumann} and Christensen, {Amalie Prien} and Haugstvedt, {Aleksander Fjeld} and Hansen, {Maria Aagaard} and Nielsen, {Christian Viggo} and Bitten Dybdal and Lars Falcon and Daniel H{\"a}gi-Pedersen and Kristian Jauho and Henrik Wolsted and Pedersen, {Christian Alves Kohler} and Sommer, {Trine Nyboe} and Kromberg, {Laurits Schou} and Kristensen, {Danja Lykke} and Svensson, {Camilla Kara} and Nielsen, {Hans Fjelds{\o}e} and S{\o}rensen, {Martin Kryspin} and Stig Jacobsen and Martin Sundskard and Nicole Brahe and Karina Jakobsen and Jensen, {Mette Skov} and Lillian Odder and Hansj{\"o}rg Selter and Mohr, {Tr{\'o}ndur H{\o}gnason} and Jensen, {Elin H} and Jensen, {Pernille Pia} and Christine Skjold and Aasvang, {Eske Kvanner}",
note = "{\textcopyright} American Society of Regional Anesthesia & Pain Medicine 2021. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2021",
month = nov,
doi = "10.1136/rapm-2021-102583",
language = "English",
volume = "46",
pages = "948--953",
journal = "Regional Anesthesia",
issn = "1098-7339",
publisher = "Lippincott Williams & Wilkins",
number = "11",

}

RIS

TY - JOUR

T1 - Waking Up in Pain

T2 - a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm

AU - Rasmussen, Anders Mølgaard

AU - Toft, Mette Helene

AU - Awada, Hussein Nasser

AU - Dirks, Jesper

AU - Brandsborg, Birgitte

AU - Rasmussen, Line Kirkegaard

AU - Kirkegaard, Ellen

AU - Hasfeldt-Hansen, Dorthe

AU - Larsen, Thomas Egemose

AU - Charalampidis, Georgios

AU - Mørk, Emilie Louise Schjøtt

AU - Rosager, Chirstine Linaa

AU - Salam, Idress Ahmad

AU - Rasmussen, Bodil Steen

AU - Jørgensen, Marlene

AU - Skjønnemand, Martin

AU - Lund, Caterina Amanti

AU - Schroder, Save

AU - Sørensen, Johan Kløvgaard

AU - Sølling, Christoffer

AU - Hansen, Kristian Kraft

AU - Rasmussen, Christina Kirkegaard

AU - Steen, Nick Phaff

AU - Nielsen, Anne Staal

AU - Geisler, Anja

AU - Køppen, Kasper Storm

AU - Pælestik, Maria Bolther

AU - Grøfte, Thorbjørn

AU - Meyhoff, Christian Sylvest

AU - Kroh, Charlotte Loumann

AU - Christensen, Amalie Prien

AU - Haugstvedt, Aleksander Fjeld

AU - Hansen, Maria Aagaard

AU - Nielsen, Christian Viggo

AU - Dybdal, Bitten

AU - Falcon, Lars

AU - Hägi-Pedersen, Daniel

AU - Jauho, Kristian

AU - Wolsted, Henrik

AU - Pedersen, Christian Alves Kohler

AU - Sommer, Trine Nyboe

AU - Kromberg, Laurits Schou

AU - Kristensen, Danja Lykke

AU - Svensson, Camilla Kara

AU - Nielsen, Hans Fjeldsøe

AU - Sørensen, Martin Kryspin

AU - Jacobsen, Stig

AU - Sundskard, Martin

AU - Brahe, Nicole

AU - Jakobsen, Karina

AU - Jensen, Mette Skov

AU - Odder, Lillian

AU - Selter, Hansjörg

AU - Mohr, Tróndur Høgnason

AU - Jensen, Elin H

AU - Jensen, Pernille Pia

AU - Skjold, Christine

AU - Aasvang, Eske Kvanner

N1 - © American Society of Regional Anesthesia & Pain Medicine 2021. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/11

Y1 - 2021/11

N2 - BACKGROUND: Acute and persistent pain after surgery is well described. However, no large-scale studies on immediate postoperative pain in the operating room (OR) exist, hindering potential areas of research to improve clinical outcomes. Thus, we aimed to describe the occurrence and severity of immediate postoperative pain in a large, unselected cohort.METHODS: This was a prospective cohort study, encompassing all procedures in 31 public hospitals in the Danish Realm, during a 5-day period including the weekend. Data on procedures and anesthesia were collected and the main outcome was occurrence of moderate or severe pain in the OR. Secondary outcomes included pain, sedation and nausea in the OR or during the first 15 min in the postanesthesia care unit (PACU) including relevant risk factors. Descriptive and logistic regression statistics were used.RESULTS: A total of 3675 procedures were included for analysis (87% inclusion rate). Moderate or severe pain occurred in 7.4% (95% CI 6.5% to 8.3%) of cases in the OR immediately after awakening, rising to 20.2% in the OR and/or PACU. Large intraprocedure and interprocedure variations occurred (0.0%-37.5%), and in 20% of cases with epidural-general anesthesia patients experienced moderate or severe pain. Independent risk factors were female sex, younger age, preoperative pain, daily opioid use and major surgical procedures.CONCLUSION: Moderate or severe pain in the immediate postoperative phase occurred in 20% of all cases with procedure and anesthesiological technique variations, suggesting a need for identification of relevant procedure-specific risk factors and development of preventive treatments.TRIAL REGISTRATION NUMBER: RoPR ID 43191.

AB - BACKGROUND: Acute and persistent pain after surgery is well described. However, no large-scale studies on immediate postoperative pain in the operating room (OR) exist, hindering potential areas of research to improve clinical outcomes. Thus, we aimed to describe the occurrence and severity of immediate postoperative pain in a large, unselected cohort.METHODS: This was a prospective cohort study, encompassing all procedures in 31 public hospitals in the Danish Realm, during a 5-day period including the weekend. Data on procedures and anesthesia were collected and the main outcome was occurrence of moderate or severe pain in the OR. Secondary outcomes included pain, sedation and nausea in the OR or during the first 15 min in the postanesthesia care unit (PACU) including relevant risk factors. Descriptive and logistic regression statistics were used.RESULTS: A total of 3675 procedures were included for analysis (87% inclusion rate). Moderate or severe pain occurred in 7.4% (95% CI 6.5% to 8.3%) of cases in the OR immediately after awakening, rising to 20.2% in the OR and/or PACU. Large intraprocedure and interprocedure variations occurred (0.0%-37.5%), and in 20% of cases with epidural-general anesthesia patients experienced moderate or severe pain. Independent risk factors were female sex, younger age, preoperative pain, daily opioid use and major surgical procedures.CONCLUSION: Moderate or severe pain in the immediate postoperative phase occurred in 20% of all cases with procedure and anesthesiological technique variations, suggesting a need for identification of relevant procedure-specific risk factors and development of preventive treatments.TRIAL REGISTRATION NUMBER: RoPR ID 43191.

KW - Analgesics, Opioid

KW - Anesthesia, General

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Pain, Postoperative/diagnosis

KW - Prospective Studies

U2 - 10.1136/rapm-2021-102583

DO - 10.1136/rapm-2021-102583

M3 - Journal article

C2 - 34408068

VL - 46

SP - 948

EP - 953

JO - Regional Anesthesia

JF - Regional Anesthesia

SN - 1098-7339

IS - 11

ER -

ID: 67149201