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Region Hovedstaden - en del af Københavns Universitetshospital
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Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach

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Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind8
Udgave nummer2
Sider (fra-til)e57647
ISSN1932-6203
DOI
StatusUdgivet - 2013

ID: 36924654