Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach

Tea Skaaby; Lise Lotte Nystrup Husemoen; Torben Martinussen; Jacob P Thyssen; Michael Melgaard; Betina Heinsbæk Thuesen; Charlotta Pisinger; Torben Jørgensen; Jeanne D Johansen; Torkil Menné; Berit Carlsen; Pal B Szecsi; Steen Stender; Runa Vavia Fenger; Mogens Fenger; Allan Linneberg

doi:10.1371/journal.pone.0057647

Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach

Tea Skaaby, Lise Lotte Nystrup Husemoen, Torben Martinussen, Jacob P Thyssen, Michael Melgaard, Betina Heinsbæk Thuesen, Charlotta Pisinger, Torben Jørgensen, Jeanne D Johansen, Torkil Menné, Berit Carlsen, Pal B Szecsi, Steen Stender, Runa Vavia Fenger, Mogens Fenger, Allan Linneberg

58 Citationer (Scopus)

Abstract

Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	2
Sider (fra-til)	e57647
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0057647
Status	Udgivet - 2013

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10.1371/journal.pone.0057647

Citationsformater

Skaaby, T., Husemoen, L. L. N., Martinussen, T., Thyssen, J. P., Melgaard, M., Thuesen, B. H., Pisinger, C., Jørgensen, T., Johansen, J. D., Menné, T., Carlsen, B., Szecsi, P. B., Stender, S., Fenger, R. V., Fenger, M., & Linneberg, A. (2013). Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach. P L o S One, 8(2), e57647. https://doi.org/10.1371/journal.pone.0057647

Skaaby, T, Husemoen, LLN, Martinussen, T, Thyssen, JP, Melgaard, M, Thuesen, BH, Pisinger, C , Jørgensen, T , Johansen, JD, Menné, T, Carlsen, B, Szecsi, PB, Stender, S, Fenger, RV, Fenger, M & Linneberg, A 2013, 'Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach', P L o S One, bind 8, nr. 2, s. e57647. https://doi.org/10.1371/journal.pone.0057647

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abstract = "Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome.",

author = "Tea Skaaby and Husemoen, {Lise Lotte Nystrup} and Torben Martinussen and Thyssen, {Jacob P} and Michael Melgaard and Thuesen, {Betina Heinsb{\ae}k} and Charlotta Pisinger and Torben J{\o}rgensen and Johansen, {Jeanne D} and Torkil Menn{\'e} and Berit Carlsen and Szecsi, {Pal B} and Steen Stender and Fenger, {Runa Vavia} and Mogens Fenger and Allan Linneberg",

year = "2013",

doi = "10.1371/journal.pone.0057647",

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T1 - Vitamin d status, filaggrin genotype, and cardiovascular risk factors

T2 - a mendelian randomization approach

AU - Skaaby, Tea

AU - Husemoen, Lise Lotte Nystrup

AU - Martinussen, Torben

AU - Thyssen, Jacob P

AU - Melgaard, Michael

AU - Thuesen, Betina Heinsbæk

AU - Pisinger, Charlotta

AU - Jørgensen, Torben

AU - Johansen, Jeanne D

AU - Menné, Torkil

AU - Carlsen, Berit

AU - Szecsi, Pal B

AU - Stender, Steen

AU - Fenger, Runa Vavia

AU - Fenger, Mogens

AU - Linneberg, Allan

PY - 2013

Y1 - 2013

N2 - Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome.

AB - Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome.

U2 - 10.1371/journal.pone.0057647

DO - 10.1371/journal.pone.0057647

M3 - Journal article

C2 - 23460889

SN - 1932-6203

VL - 8

SP - e57647

JO - P L o S One

JF - P L o S One

IS - 2

ER -

Vitamin d status, filaggrin genotype, and cardiovascular risk factors: a mendelian randomization approach

Abstract

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