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Vitamin D deficiency and airflow limitation in the Baltimore Longitudinal Study of Ageing

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  • Mia Moberg
  • Palchamy Elango
  • Luigi Ferrucci
  • Martijn A Spruit
  • Emiel F Wouters
  • Erica P A Rutten
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BACKGROUND: Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD) and has also been linked to comorbidities often present in COPD.

AIM: The aim of this study was to investigate whether vitamin D deficiency was related specifically to airflow limitation or whether vitamin D deficiency was determined by conditions that frequently coexist with COPD: insulin resistance, hypertension, anaemia, obesity and hypercholesterolaemia.

METHODS: For this cross-sectional analysis, we included 897 subjects from the Baltimore Longitudinal Study of Aging. Subjects taking vitamin D supplements were excluded. Airflow limitation was defined as FEV1 /FVC < lower limit of normal. Logistic regression was used to assess the association between vitamin D deficiency (25-hydroxy vitamin D < 20 ng/mL) and possible determinants.

RESULTS: Vitamin D deficiency was not specific for subjects with airflow limitation. Body mass index (BMI) (OR: 1·05, P < 0·03) and obesity (BMI > 30 kg/m(2) ) (OR: 1·9, P < 0·002) were significantly associated with vitamin D deficiency in the adjusted multivariate regression analysis. Physical activity was associated with a decreased risk of vitamin D deficiency.

CONCLUSIONS: Airflow limitation was not an independent determinant of vitamin D deficiency. The effect of weight loss and increased physical activity on vitamin D levels should be investigated further in intervention studies.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Investigation
Vol/bind45
Udgave nummer9
Sider (fra-til)955-63
Antal sider9
ISSN0014-2972
DOI
StatusUdgivet - sep. 2015
Eksternt udgivetJa

ID: 45583222