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Vitamin D, carotid intima-media thickness, and bone structure in patients with type 2 diabetes

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@article{92eebc605e654920b2abaa99ff28d7d3,
title = "Vitamin D, carotid intima-media thickness, and bone structure in patients with type 2 diabetes",
abstract = "Despite aggressive treatment of cardiovascular disease (CVD) risk factors individuals with type 2 diabetes (T2D) still have increased risk of cardiovascular morbidity and mortality. The primary aim of this study was to examine the cross-sectional association between total (25(OH)D) and risk of CVD in patients with T2D. Secondary objective was to examine the association between 25(OH)D and bone health. A Danish cohort of patients with T2D participating in a randomised clinical trial were analysed. In total 415 patients (68 {\%} men, age 60±9 years (mean±SD), duration of diabetes 12±6 years), including 294 patients (71{\%}) treated with insulin. Carotid intima-media thickness (IMT) and arterial stiffness (carotid artery distensibility coefficient (DC) and Young's elastic modulus (YEM)) were measured by ultrasound scan as indicators of CVD. Bone health was assessed by bone mineral density (BMD) and trabecular bone score (TBS) measured by Dual energy X-ray absorptiometry (DXA). In this cohort, 214 patients (52 {\%}) were vitamin D deficient (25(OH)D < 50 nmol/l). Carotid IMT was 0.793±0.137 mm, DC was 0.0030±0.001 mmHg-1, YEM was 2354±1038 mmHg and 13 (3{\%}) of the patients were diagnosed with osteoporosis. 25(OH)D level was not associated with carotid IMT or arterial stiffness (P > 0.3) or bone health (P > 0.6) after adjustment for CVD risk factors. In conclusion, 25(OH)D status was not associated with carotid IMT, arterial stiffness or bone health in this cohort of patients with T2D. To explore these associations and the association with other biomarkers further, multicentre studies with large numbers of patients are required.",
author = "Karoline Winckler and Lise Tarnow and Christensen, {Louise Lundby} and Almdal, {Thomas Peter} and Niels Wiinberg and Pia Eiken and Boesgaard, {Trine Well{\o}v} and {CIMT trial group (Bianca Hemmingsen, member)} and Bianca Hemmingsen",
year = "2015",
month = "5",
day = "8",
doi = "10.1530/EC-15-0034",
language = "English",
volume = "4",
pages = "128--135",
journal = "Endocrine Connections",
issn = "2049-3614",
publisher = "BioScientifica Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Vitamin D, carotid intima-media thickness, and bone structure in patients with type 2 diabetes

AU - Winckler, Karoline

AU - Tarnow, Lise

AU - Christensen, Louise Lundby

AU - Almdal, Thomas Peter

AU - Wiinberg, Niels

AU - Eiken, Pia

AU - Boesgaard, Trine Welløv

AU - CIMT trial group (Bianca Hemmingsen, member)

A2 - Hemmingsen, Bianca

PY - 2015/5/8

Y1 - 2015/5/8

N2 - Despite aggressive treatment of cardiovascular disease (CVD) risk factors individuals with type 2 diabetes (T2D) still have increased risk of cardiovascular morbidity and mortality. The primary aim of this study was to examine the cross-sectional association between total (25(OH)D) and risk of CVD in patients with T2D. Secondary objective was to examine the association between 25(OH)D and bone health. A Danish cohort of patients with T2D participating in a randomised clinical trial were analysed. In total 415 patients (68 % men, age 60±9 years (mean±SD), duration of diabetes 12±6 years), including 294 patients (71%) treated with insulin. Carotid intima-media thickness (IMT) and arterial stiffness (carotid artery distensibility coefficient (DC) and Young's elastic modulus (YEM)) were measured by ultrasound scan as indicators of CVD. Bone health was assessed by bone mineral density (BMD) and trabecular bone score (TBS) measured by Dual energy X-ray absorptiometry (DXA). In this cohort, 214 patients (52 %) were vitamin D deficient (25(OH)D < 50 nmol/l). Carotid IMT was 0.793±0.137 mm, DC was 0.0030±0.001 mmHg-1, YEM was 2354±1038 mmHg and 13 (3%) of the patients were diagnosed with osteoporosis. 25(OH)D level was not associated with carotid IMT or arterial stiffness (P > 0.3) or bone health (P > 0.6) after adjustment for CVD risk factors. In conclusion, 25(OH)D status was not associated with carotid IMT, arterial stiffness or bone health in this cohort of patients with T2D. To explore these associations and the association with other biomarkers further, multicentre studies with large numbers of patients are required.

AB - Despite aggressive treatment of cardiovascular disease (CVD) risk factors individuals with type 2 diabetes (T2D) still have increased risk of cardiovascular morbidity and mortality. The primary aim of this study was to examine the cross-sectional association between total (25(OH)D) and risk of CVD in patients with T2D. Secondary objective was to examine the association between 25(OH)D and bone health. A Danish cohort of patients with T2D participating in a randomised clinical trial were analysed. In total 415 patients (68 % men, age 60±9 years (mean±SD), duration of diabetes 12±6 years), including 294 patients (71%) treated with insulin. Carotid intima-media thickness (IMT) and arterial stiffness (carotid artery distensibility coefficient (DC) and Young's elastic modulus (YEM)) were measured by ultrasound scan as indicators of CVD. Bone health was assessed by bone mineral density (BMD) and trabecular bone score (TBS) measured by Dual energy X-ray absorptiometry (DXA). In this cohort, 214 patients (52 %) were vitamin D deficient (25(OH)D < 50 nmol/l). Carotid IMT was 0.793±0.137 mm, DC was 0.0030±0.001 mmHg-1, YEM was 2354±1038 mmHg and 13 (3%) of the patients were diagnosed with osteoporosis. 25(OH)D level was not associated with carotid IMT or arterial stiffness (P > 0.3) or bone health (P > 0.6) after adjustment for CVD risk factors. In conclusion, 25(OH)D status was not associated with carotid IMT, arterial stiffness or bone health in this cohort of patients with T2D. To explore these associations and the association with other biomarkers further, multicentre studies with large numbers of patients are required.

U2 - 10.1530/EC-15-0034

DO - 10.1530/EC-15-0034

M3 - Journal article

VL - 4

SP - 128

EP - 135

JO - Endocrine Connections

JF - Endocrine Connections

SN - 2049-3614

IS - 2

ER -

ID: 45347424