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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Vitamin D, Cardiovascular Disease and Risk Factors

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Vis graf over relationer

Observational studies have suggested a possible protective role of vitamin D on the cardiovascular system. The available evidence does not support either cardiovascular benefits or harms of vitamin D supplementation. This chapter provides an overview and discussion of the current knowledge of vitamin D effects from a cardiovascular health perspective. It focuses on vitamin D in relation to cardiovascular disease, i.e. ischemic heart disease, and stroke; the traditional cardiovascular risk factors hypertension, abnormal blood lipids, obesity; and the emerging risk factors hyperparathyroidism, microalbuminuria, chronic obstructive pulmonary diseases, and non-alcoholic fatty liver disease. Meta-analyses of observational studies have largely found vitamin D levels to be inversely associated with cardiovascular risk and disease. However, Mendelian randomization studies and randomized, controlled trials (RCTs) have not been able to consistently replicate the observational findings. Several RCTs are ongoing, and the results from these are needed to clarify whether vitamin D deficiency is a causal and reversible factor to prevent cardiovascular disease.

OriginalsprogEngelsk
BogserieAdvances in Experimental Medicine and Biology
Vol/bind996
Sider (fra-til)221-230
Antal sider10
ISSN0065-2598
DOI
StatusUdgivet - 2017

ID: 52362145