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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Visual steady state in relation to age and cognitive function

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  1. Reward signalling in brainstem nuclei under fluctuating blood glucose

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Experiences managing pregnant hospital staff members using an active management policy-A qualitative study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Histological outcomes in HPV-screened elderly women in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Brain capillary pericytes and neurovascular coupling

    Publikation: Bidrag til tidsskriftReviewpeer review

  2. ATP induces contraction of cultured brain capillary pericytes via activation of P2Y-type purinergic receptors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Male fertility before and after androgen abuse

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Tidligt skift fra intravenøs fra intravenøs til antibiotikabehandling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Neocortical gamma activity is crucial for sensory perception and cognition. This study examines the value of using non-task stimulation-induced EEG oscillations to predict cognitive status in a birth cohort of healthy Danish males (Metropolit) with varying cognitive ability. In particular, we examine the steady-state VEP power response (SSVEP-PR) in the alpha (8Hz) and gamma (36Hz) bands in 54 males (avg. age: 62.0 years) and compare these with 10 young healthy participants (avg. age 27.6 years). Furthermore, we correlate the individual alpha-to-gamma difference in relative visual-area power (ΔRV) with cognitive scores for the older adults. We find that ΔRV decrease with age by just over one standard deviation when comparing young with old participants (p<0.01). Furthermore, intelligence is significantly negatively correlated with ΔRV in the older adult cohort, even when processing speed, global cognition, executive function, memory, and education (p<0.05). In our preferred specification, an increase in ΔRV of one standard deviation is associated with a reduction in intelligence of 48% of a standard deviation (p<0.01). Finally, we conclude that the difference in cerebral rhythmic activity between the alpha and gamma bands is associated with age and cognitive status, and that ΔRV therefore provide a non-subjective clinical tool with which to examine cognitive status in old age.

OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind12
Udgave nummer2
Sider (fra-til)e0171859
ISSN1932-6203
DOI
StatusUdgivet - 2017

ID: 52613788