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Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

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Vis graf over relationer

Intrathecal antibody synthesis to viruses is associated with multiple sclerosis (MS). Here, IgG levels to Epstein-Barr virus (EBV) BamHI-A rightward frame 1 (BARF1), EBV nuclear antigen 1 (EBNA1), mumps virus (MuV) nucleoprotein (NuP), measles virus (MeV) NuP and rubella virus (RuV) capsid protein (CaP) were found to be elevated in serum and cerebrospinal fluid (CSF) of MS patients compared to healthy controls (HCs), whereas the opposite was found for cytomegalovirus (CMV) pp52. Strong correlations between serum and CSF IgG were seen for MeV, CMV and RuV in both MS patients and HCs. The antigen panel obtained high sensitivity (81%) and specificity (86%), demonstrating that antigen panels may supplement the total IgG index used in MS diagnosis.

OriginalsprogEngelsk
Artikelnummer577868
TidsskriftJournal of Neuroimmunology
Vol/bind367
Antal sider9
ISSN0165-5728
DOI
StatusUdgivet - 15 jun. 2022

Bibliografisk note

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