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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Virus-like particle display of HER2 induces potent anti-cancer responses

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  1. The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines

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  2. Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

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  3. Neo-antigen specific memory T-cell responses in healthy individuals

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  4. Immunoprofiles of colorectal cancer from Lynch syndrome

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  5. Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma

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  1. Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

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  2. Labour market affiliation among non-bullied colleagues at work units with reported bullying

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  3. Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

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  4. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

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  5. A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine

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Vis graf over relationer

Overexpression of human epidermal growth factor receptor-2 (HER2) occurs in 20-30% of invasive breast cancers. Monoclonal antibody therapy is effective in treating HER2-driven mammary carcinomas, but its utility is limited by high costs, side effects and development of resistance. Active vaccination may represent a safer, more effective and cheaper alternative, although the induction of strong and durable autoantibody responses is hampered by immune-tolerogenic mechanisms. Using a novel virus-like particle (VLP) based vaccine platform we show that directional, high-density display of human HER2 on the surface of VLPs, allows induction of therapeutically potent anti-HER2 autoantibody responses. Prophylactic vaccination reduced spontaneous development of mammary carcinomas by 50%-100% in human HER2 transgenic mice and inhibited the growth of HER2-positive tumors implanted in wild-type mice. The HER2-VLP vaccine shows promise as a new cost-effective modality for prevention and treatment of HER2-positive cancer. The VLP platform may represent an effective tool for development of vaccines against other non-communicable diseases.

OriginalsprogEngelsk
TidsskriftOncoImmunology
Vol/bind7
Udgave nummer3
Sider (fra-til)e1408749
ISSN2162-4011
DOI
StatusUdgivet - 2018

ID: 56460219