Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Virtual reality assessment of daily life executive functions in mood disorders: associations with neuropsychological and functional measures

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Exposure to passive smoking during adolescence is associated with an increased risk of developing multiple sclerosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hippocampal subfield morphology in monozygotic twins discordant for affective disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Serum ferritin level is inversely related to number of previous pregnancy losses in women with recurrent pregnancy loss

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prevalence of SARS-CoV-2 IgG/IgM Antibodies among Danish and Swedish Falck Emergency and Non-Emergency Healthcare Workers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Mood disorders are often accompanied by cognitive difficulties that impede patients' functional capacity. However, neuropsychological tests provide limited insight into patients' ability to tackle daily life cognitive challenges. To address this challenge, we investigated the sensitivity and validity of the Jansari assessment of Executive Functions (JEF©) virtual reality test in patients with mood disorders and its associations with functional capacity.

METHODS: In total, 21 patients with bipolar disorder or unipolar disorder in full or partial remission and 29 healthy control participants were recruited for the study. Participants attended one test session during which they underwent diagnostic assessments, mood ratings and assessments with JEF©, a battery of standard neuropsychological tests (RAVLT, Trial Making A and B, Fluency tests, letter-number sequencing and RBANS digit span and coding tests) and functional capacity measures (UPSA-B and FAST).

RESULTS: Patients showed impaired executive functions on JEF© compared to the control group. Relative to the control group, patients were also impaired on neuropsychological sub-composite scores of executive function, verbal memory and processing speed as well as on a global cognition composite score. In addition, JEF© scores predicted performance on a global cognition composite based on neuropsychological tests, and a performance-based measure of functional capacity.

LIMITATIONS: This study had a relatively small sample size and included a mixed group of patients with unipolar or bipolar disorder.

CONCLUSIONS: JEF© is a sensitive and valid measure of daily life executive impairments in patients with mood disorders that is associated with functional capacity.

OriginalsprogEngelsk
TidsskriftJournal of Affective Disorders
Vol/bind280
Udgave nummerPt A
Sider (fra-til)478-487
Antal sider10
ISSN0165-0327
DOI
StatusUdgivet - 1 feb. 2021

Bibliografisk note

Copyright © 2020. Published by Elsevier B.V.

ID: 61455820