Virkninger af glukagonlignende peptider på galdeblæremotiliteten

Ida M Gether, Christina Nexøe-Larsen, David P Sonne, Filip K Knop

Abstract

As cases of gallbladder-related adverse events have been reported in patients treated with glucagon-like peptide (GLP)-1 receptor agonists and GLP-2 receptor agonists, studies have investigated the effects of these hormones on the enterohepatic circulation of bile acids and gallbladder motility. Results suggest, that bile acids and GLP-2 counteract postprandial cholecystokinin-mediated gallbladder contraction, while GLP-1 may delay gallbladder refilling. This provides important information on the effect and safety of drugs based on GLP-1 and GLP-2, respectively.

Bidragets oversatte titelEffects of glucagon-like peptides on gallbladder motility
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind180
Udgave nummer50
ISSN0041-5782
StatusUdgivet - 10 dec. 2018

Emneord

  • Bile Acids and Salts
  • Cholecystokinin
  • Gallbladder/physiology
  • Glucagon-Like Peptide 1/physiology
  • Humans

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