Virkninger af glukagonlignende peptider på galdeblæremotiliteten

Ida M Gether; Christina Nexøe-Larsen; David P Sonne; Filip K Knop

Virkninger af glukagonlignende peptider på galdeblæremotiliteten

Ida M Gether, Christina Nexøe-Larsen, David P Sonne, Filip K Knop

Abstrakt

As cases of gallbladder-related adverse events have been reported in patients treated with glucagon-like peptide (GLP)-1 receptor agonists and GLP-2 receptor agonists, studies have investigated the effects of these hormones on the enterohepatic circulation of bile acids and gallbladder motility. Results suggest, that bile acids and GLP-2 counteract postprandial cholecystokinin-mediated gallbladder contraction, while GLP-1 may delay gallbladder refilling. This provides important information on the effect and safety of drugs based on GLP-1 and GLP-2, respectively.

Bidragets oversatte titel	Effects of glucagon-like peptides on gallbladder motility
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	180
Udgave nummer	50
ISSN	0041-5782
Status	Udgivet - 10 dec. 2018

Emneord

Bile Acids and Salts
Cholecystokinin
Gallbladder/physiology
Glucagon-Like Peptide 1/physiology
Humans

Citationsformater

@article{790c5d9ec0bd47909a5525b410b045b2,

title = "Virkninger af glukagonlignende peptider p{\aa} galdebl{\ae}remotiliteten",

abstract = "As cases of gallbladder-related adverse events have been reported in patients treated with glucagon-like peptide (GLP)-1 receptor agonists and GLP-2 receptor agonists, studies have investigated the effects of these hormones on the enterohepatic circulation of bile acids and gallbladder motility. Results suggest, that bile acids and GLP-2 counteract postprandial cholecystokinin-mediated gallbladder contraction, while GLP-1 may delay gallbladder refilling. This provides important information on the effect and safety of drugs based on GLP-1 and GLP-2, respectively.",

keywords = "Bile Acids and Salts, Cholecystokinin, Gallbladder/physiology, Glucagon-Like Peptide 1/physiology, Humans",

author = "Gether, {Ida M} and Christina Nex{\o}e-Larsen and Sonne, {David P} and Knop, {Filip K}",

year = "2018",

month = dec,

day = "10",

language = "Dansk",

volume = "180",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "50",

}

TY - JOUR

T1 - Virkninger af glukagonlignende peptider på galdeblæremotiliteten

AU - Gether, Ida M

AU - Nexøe-Larsen, Christina

AU - Sonne, David P

AU - Knop, Filip K

PY - 2018/12/10

Y1 - 2018/12/10

N2 - As cases of gallbladder-related adverse events have been reported in patients treated with glucagon-like peptide (GLP)-1 receptor agonists and GLP-2 receptor agonists, studies have investigated the effects of these hormones on the enterohepatic circulation of bile acids and gallbladder motility. Results suggest, that bile acids and GLP-2 counteract postprandial cholecystokinin-mediated gallbladder contraction, while GLP-1 may delay gallbladder refilling. This provides important information on the effect and safety of drugs based on GLP-1 and GLP-2, respectively.

AB - As cases of gallbladder-related adverse events have been reported in patients treated with glucagon-like peptide (GLP)-1 receptor agonists and GLP-2 receptor agonists, studies have investigated the effects of these hormones on the enterohepatic circulation of bile acids and gallbladder motility. Results suggest, that bile acids and GLP-2 counteract postprandial cholecystokinin-mediated gallbladder contraction, while GLP-1 may delay gallbladder refilling. This provides important information on the effect and safety of drugs based on GLP-1 and GLP-2, respectively.

KW - Bile Acids and Salts

KW - Cholecystokinin

KW - Gallbladder/physiology

KW - Glucagon-Like Peptide 1/physiology

KW - Humans

M3 - Tidsskriftartikel

C2 - 30547877

VL - 180

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 50

ER -

Virkninger af glukagonlignende peptider på galdeblæremotiliteten

Abstrakt

Emneord

Fingeraftryk

Citationsformater