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Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark

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Weis, Nina ; Cowan, Susan ; Hallager, Sofie ; Dröse, Sandra ; Kristensen, Lena Hagelskjær ; Grønbæk, Karin ; Gerstoft, Jan ; Madsen, Lone G ; Clausen, Mette Rye ; Lunding, Suzanne ; Tarp, Britta D ; Barfod, Toke S ; Sloth, Stine ; Holm, Dorte Kinggaard ; Jensen, Jesper ; Krarup, Henrik. / Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark. I: Scandinavian Journal of Gastroenterology. 2017 ; Bind 52, Nr. 2. s. 178-184.

Bibtex

@article{9f34c06fefdb41f5bbcb207b7a619d16,
title = "Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark",
abstract = "OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission.MATERIALS AND METHODS: Through the Danish Database for Hepatitis B and C, we identified 589 HBV-infected women who had given birth to 686 children, of whom 370 children were born to 322 women referred to hospital. 132 (36{\%}) children, born to 109 mothers, were included in the study; 128 children had blood samples tested for HBsAg, anti-HBc (total), anti-HBs and HBV-DNA and four children had saliva samples tested for anti-HBc.RESULTS: We found vertical HBV transmission in Denmark to be 2.3{\%} [95{\%} CI: 0.5, 6.5], a high proportion of HBsAg-negative children with low levels of anti-HBs (18.4{\%}) and a high proportion (15.2{\%}) with resolved HBV infection. No maternal risk factor was statistically significantly associated with HBV vertical transmission.CONCLUSION: In a HBV low prevalence setting as Denmark, despite a national vaccination program, vertical HBV transmission occurred in 2.3{\%} of children born to HBV-infected mothers. In addition, a high proportion of the children had insufficient anti-HBs levels and a high proportion had serological signs of resolved HBV infection.",
author = "Nina Weis and Susan Cowan and Sofie Hallager and Sandra Dr{\"o}se and Kristensen, {Lena Hagelskj{\ae}r} and Karin Gr{\o}nb{\ae}k and Jan Gerstoft and Madsen, {Lone G} and Clausen, {Mette Rye} and Suzanne Lunding and Tarp, {Britta D} and Barfod, {Toke S} and Stine Sloth and Holm, {Dorte Kinggaard} and Jesper Jensen and Henrik Krarup",
year = "2017",
doi = "10.1080/00365521.2016.1244704",
language = "English",
volume = "52",
pages = "178--184",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Vertical transmission of hepatitis B virus during pregnancy and delivery in Denmark

AU - Weis, Nina

AU - Cowan, Susan

AU - Hallager, Sofie

AU - Dröse, Sandra

AU - Kristensen, Lena Hagelskjær

AU - Grønbæk, Karin

AU - Gerstoft, Jan

AU - Madsen, Lone G

AU - Clausen, Mette Rye

AU - Lunding, Suzanne

AU - Tarp, Britta D

AU - Barfod, Toke S

AU - Sloth, Stine

AU - Holm, Dorte Kinggaard

AU - Jensen, Jesper

AU - Krarup, Henrik

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission.MATERIALS AND METHODS: Through the Danish Database for Hepatitis B and C, we identified 589 HBV-infected women who had given birth to 686 children, of whom 370 children were born to 322 women referred to hospital. 132 (36%) children, born to 109 mothers, were included in the study; 128 children had blood samples tested for HBsAg, anti-HBc (total), anti-HBs and HBV-DNA and four children had saliva samples tested for anti-HBc.RESULTS: We found vertical HBV transmission in Denmark to be 2.3% [95% CI: 0.5, 6.5], a high proportion of HBsAg-negative children with low levels of anti-HBs (18.4%) and a high proportion (15.2%) with resolved HBV infection. No maternal risk factor was statistically significantly associated with HBV vertical transmission.CONCLUSION: In a HBV low prevalence setting as Denmark, despite a national vaccination program, vertical HBV transmission occurred in 2.3% of children born to HBV-infected mothers. In addition, a high proportion of the children had insufficient anti-HBs levels and a high proportion had serological signs of resolved HBV infection.

AB - OBJECTIVE: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to mothers with chronic HBV infection, to investigate the antibody response in the children and to investigate possible maternal predictive risk factors for HBV transmission.MATERIALS AND METHODS: Through the Danish Database for Hepatitis B and C, we identified 589 HBV-infected women who had given birth to 686 children, of whom 370 children were born to 322 women referred to hospital. 132 (36%) children, born to 109 mothers, were included in the study; 128 children had blood samples tested for HBsAg, anti-HBc (total), anti-HBs and HBV-DNA and four children had saliva samples tested for anti-HBc.RESULTS: We found vertical HBV transmission in Denmark to be 2.3% [95% CI: 0.5, 6.5], a high proportion of HBsAg-negative children with low levels of anti-HBs (18.4%) and a high proportion (15.2%) with resolved HBV infection. No maternal risk factor was statistically significantly associated with HBV vertical transmission.CONCLUSION: In a HBV low prevalence setting as Denmark, despite a national vaccination program, vertical HBV transmission occurred in 2.3% of children born to HBV-infected mothers. In addition, a high proportion of the children had insufficient anti-HBs levels and a high proportion had serological signs of resolved HBV infection.

U2 - 10.1080/00365521.2016.1244704

DO - 10.1080/00365521.2016.1244704

M3 - Journal article

VL - 52

SP - 178

EP - 184

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 2

ER -

ID: 49157417