Abstract
Epstein-Barr virus (EBV) is associated with 8% of gastric carcinomas (GC) worldwide, being the most frequent EBV-associated malignancy with 80,000 new cases per year. The association is based on the presence of clonal EBV products in gastric tumour cells, and elevated EBV antibodies in pre-diagnostic sera. EBV-associated GC are twice as common in males and often associated to cancer in the cardia-region. Gastric surgery increases the risk significantly. Until now, no clear interaction between Helicobacter pylori, the single most important risk factor for GC, and EBV has been established.
Bidragets oversatte titel | Gastric carcinoma is the most frequent Epstein-Barr virus-associated malignancy |
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Originalsprog | Dansk |
Tidsskrift | Ugeskrift for Laeger |
Vol/bind | 175 |
Udgave nummer | 47A |
ISSN | 0041-5782 |
Status | Udgivet - 18 nov. 2013 |
Udgivet eksternt | Ja |
Emneord
- Carcinoma/epidemiology
- Epstein-Barr Virus Infections/complications
- Herpesvirus 4, Human/genetics
- Humans
- Male
- Stomach Neoplasms/epidemiology