Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Ventricular repolarization alterations in women with angina pectoris and suspected coronary microvascular dysfunction

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Type 1 diabetes is associated with T-wave morphology changes. The Thousand & 1 Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Spatial QRS-T angle variants for prediction of all-cause mortality

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Women with coronary microvascular dysfunction and no obstructive coronary artery disease have reduced exercise capacity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pro-inflammatory biomarkers in women with non-obstructive angina pectoris and coronary microvascular dysfunction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD.

METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch. CMD was assessed as a coronary flow velocity reserve (CFVR) by transthoracic echocardiography.

RESULTS: Women with angina pectoris had significantly longer QTc intervals (429±20ms) and increased MCS (IQR) (0.73 [0.64-0.80]) compared with the controls (419±20ms) and (0.63 [(0.53-0.73]), respectively (both p<0.001). CFVR was associated with longer QTc interval (p=0.02), but the association was attenuated after multivariable adjustment (p=0.08).

CONCLUSION: This study suggests that women with angina pectoris have alterations in T-wave morphology as well as longer QTc interval compared with a reference population. CMD might be an explanation.

OriginalsprogEngelsk
TidsskriftJournal of Electrocardiology
Vol/bind51
Udgave nummer1
Sider (fra-til)15-20
ISSN0022-0736
DOI
StatusUdgivet - feb. 2018

ID: 51705431