Ventilation inhomogeneity in children with primary ciliary dyskinesia

Kent Green, Frederik F Buchvald, June Kehlet Marthin, Birgitte Hanel, Per M Gustafsson, Kim Gjerum Nielsen*

*Corresponding author af dette arbejde
94 Citationer (Scopus)

Abstract

The lung clearance index (LCI) derived from the multiple breath inert gas washout (MBW) test reflects global ventilation distribution inhomogeneity. It is more sensitive than forced expiratory volume in 1 s (FEV(1)) for detecting abnormal airway function and correlates closely with structural lung damage in children with cystic fibrosis, which shares features with primary ciliary dyskinesia (PCD). Normalised phase III slope indices S(cond) and S(acin) reflect function of the small conducting and acinar airways, respectively. The involvement of the peripheral airways assessed by MBW tests has not been previously described in PCD.
OriginalsprogEngelsk
TidsskriftThorax
Vol/bind67
Udgave nummer1
Sider (fra-til)49-53
Antal sider5
ISSN0040-6376
DOI
StatusUdgivet - 2012

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