Atherosclerosis of coronary arteries can result in a hypoxic state where myocardial cells may become dysfunctional or die. The oxygen sensing transcription factor hypoxia inducible factor 1 responds to low oxygen levels by elevating the production of angiogenic growth factors, such as vascular endothelial growth factor (VEGF). Despite this, endogenous processes and conventional therapies are inefficient in some patients. To stimulate angiogenesis, VEGF has been injected into the myocardium. As stated in this review, this therapy has so far been proven safe and studies are conducted in several countries, including Denmark.

Bidragets oversatte titelVascular endothelial growth factor therapy in ischaemic heart disease
TidsskriftUgeskrift for Laeger
Udgave nummer44
StatusUdgivet - 26 okt. 2020


Dyk ned i forskningsemnerne om 'Vaskulær endotelial vækstfaktor-terapi ved iskæmisk hjertesygdom.'. Sammen danner de et unikt fingeraftryk.