@article{23604820372e11dfa3b3000ea68e967b,
title = "Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol",
abstract = "BACKGROUND: Variations in the serotonin transporter gene (5-HTTLPR) and stressful life events are associated with affective disorders. AIM: To investigate whether the distribution of the alleles of the 5-HTTLPR is associated with a genetic predisposition to affective disorder and whether these variations interact with life events in relation to depressive symptoms, neuroticism and salivary cortisol. METHOD: In a high-risk population study, healthy monozygotic and dizygotic twins with (high-risk twins) and without (low-risk twins) a co-twin history of affective disorder were identified through nationwide registers. RESULTS: When comparing the 81 individuals homozygote for the long allele with the 125 individuals hetero- and homozygote for the short allele no associations between the allele distribution and a genetic predisposition were found. The presence of the short allele of the 5-HTTLPR and the experience of SLE was associated with a higher neuroticism score, but not with depressive symptoms nor awakening or evening salivary cortisol. CONCLUSION: A combination of variants in 5-HTTLPR and environmental stress seems to increase neuroticism in healthy individuals.",
author = "Maj Vinberg and Erling Mellerup and Andersen, {Per Kragh} and Bente Bennike and Kessing, {Lars Vedel}",
note = "Copyright 2009 Elsevier Inc. All rights reserved.",
year = "2009",
doi = "10.1016/j.pnpbp.2009.10.002",
language = "English",
volume = "34",
pages = "86--91",
journal = "Progress in neuro-psychopharmacology & biological psychiatry",
issn = "1878-4216",
publisher = "Elsevier Inc.",
number = "1",
}