Variance decomposition of apolipoproteins and lipids in Danish twins.

Mogens Fenger; Karoline Schousboe; Thorkild I A Sørensen; Kirsten O Kyvik

doi:10.1016/j.atherosclerosis.2006.04.024

Variance decomposition of apolipoproteins and lipids in Danish twins.

Mogens Fenger, Karoline Schousboe, Thorkild I A Sørensen, Kirsten O Kyvik

Klinisk Biokemisk Afdeling AHH

17 Citationer (Scopus)

Abstract

OBJECTIVE: Twin studies are used extensively to decompose the variance of a trait, mainly to estimate the heritability of the trait. A second purpose of such studies is to estimate to what extent the non-genetic variance is shared or specific to individuals. To a lesser extent the twin studies have been used in bivariate or multivariate analysis to elucidate common genetic factors to two or more traits. METHODS AND RESULTS: In the present study the variances of traits related to lipid metabolism is decomposed in a relatively large Danish twin population, including bivariate analysis to detect possible common genetic factors of the traits. CONCLUSIONS: The heritabilities of apolipoprotein B and E, cholesterol, LDL, and high density lipoprotein (HDL) were significant in the general population, although gender-specific levels and significance were detected. Heritabilities of apolipoprotein A1, triglycerides, and very low density protein (VLDL) were only significant when the population was stratified according to gender.
Udgivelsesdato: 2007-Mar

Originalsprog	Engelsk
Tidsskrift	Atherosclerosis
Vol/bind	191
Udgave nummer	1
Sider (fra-til)	40-7
Antal sider	7
ISSN	0021-9150
DOI	https://doi.org/10.1016/j.atherosclerosis.2006.04.024
Status	Udgivet - 2007

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10.1016/j.atherosclerosis.2006.04.024

Citationsformater

@article{09b2afbe4ff54df5903d77fab08124d1,

title = "Variance decomposition of apolipoproteins and lipids in Danish twins.",

abstract = "Diffusion weighted imaging (DWI) and tractography allow the non-invasive study of anatomical brain connectivity. However, a gold standard for validating tractography of complex connections is lacking. Using the porcine brain as a highly gyrated brain model, we quantitatively and qualitatively assessed the anatomical validity and reproducibility of in vitro multi-fiber probabilistic tractography against two invasive tracers: the histochemically detectable biotinylated dextran amine and manganese enhanced magnetic resonance imaging. Post mortem DWI was used to ensure that most of the sources known to degrade the anatomical accuracy of in vivo DWI did not influence the tracking results. We demonstrate that probabilistic tractography reliably detected specific pathways. Moreover, the applied model allowed identification of the limitations that are likely to appear in many of the current tractography methods. Nevertheless, we conclude that DWI tractography can be a precise tool in studying anatomical brain connectivity.",

keywords = "Adult, Aged, Apolipoproteins, Cholesterol, Denmark, Female, Humans, Lipoproteins, Male, Middle Aged, Multivariate Analysis, Quantitative Trait, Heritable, Sex Factors, Triglycerides",

author = "Mogens Fenger and Karoline Schousboe and S{\o}rensen, {Thorkild I A} and Kyvik, {Kirsten O}",

year = "2007",

doi = "10.1016/j.atherosclerosis.2006.04.024",

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T1 - Variance decomposition of apolipoproteins and lipids in Danish twins.

AU - Fenger, Mogens

AU - Schousboe, Karoline

AU - Sørensen, Thorkild I A

AU - Kyvik, Kirsten O

PY - 2007

Y1 - 2007

N2 - Diffusion weighted imaging (DWI) and tractography allow the non-invasive study of anatomical brain connectivity. However, a gold standard for validating tractography of complex connections is lacking. Using the porcine brain as a highly gyrated brain model, we quantitatively and qualitatively assessed the anatomical validity and reproducibility of in vitro multi-fiber probabilistic tractography against two invasive tracers: the histochemically detectable biotinylated dextran amine and manganese enhanced magnetic resonance imaging. Post mortem DWI was used to ensure that most of the sources known to degrade the anatomical accuracy of in vivo DWI did not influence the tracking results. We demonstrate that probabilistic tractography reliably detected specific pathways. Moreover, the applied model allowed identification of the limitations that are likely to appear in many of the current tractography methods. Nevertheless, we conclude that DWI tractography can be a precise tool in studying anatomical brain connectivity.

AB - Diffusion weighted imaging (DWI) and tractography allow the non-invasive study of anatomical brain connectivity. However, a gold standard for validating tractography of complex connections is lacking. Using the porcine brain as a highly gyrated brain model, we quantitatively and qualitatively assessed the anatomical validity and reproducibility of in vitro multi-fiber probabilistic tractography against two invasive tracers: the histochemically detectable biotinylated dextran amine and manganese enhanced magnetic resonance imaging. Post mortem DWI was used to ensure that most of the sources known to degrade the anatomical accuracy of in vivo DWI did not influence the tracking results. We demonstrate that probabilistic tractography reliably detected specific pathways. Moreover, the applied model allowed identification of the limitations that are likely to appear in many of the current tractography methods. Nevertheless, we conclude that DWI tractography can be a precise tool in studying anatomical brain connectivity.

KW - Adult

KW - Aged

KW - Apolipoproteins

KW - Cholesterol

KW - Denmark

KW - Female

KW - Humans

KW - Lipoproteins

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Quantitative Trait, Heritable

KW - Sex Factors

KW - Triglycerides

U2 - 10.1016/j.atherosclerosis.2006.04.024

DO - 10.1016/j.atherosclerosis.2006.04.024

M3 - Journal article

C2 - 16730014

SN - 0021-9150

VL - 191

SP - 40

EP - 47

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

Variance decomposition of apolipoproteins and lipids in Danish twins.

Abstract

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