Variance decomposition of apolipoproteins and lipids in Danish twins.

Mogens Fenger, Karoline Schousboe, Thorkild I A Sørensen, Kirsten O Kyvik

17 Citationer (Scopus)


OBJECTIVE: Twin studies are used extensively to decompose the variance of a trait, mainly to estimate the heritability of the trait. A second purpose of such studies is to estimate to what extent the non-genetic variance is shared or specific to individuals. To a lesser extent the twin studies have been used in bivariate or multivariate analysis to elucidate common genetic factors to two or more traits. METHODS AND RESULTS: In the present study the variances of traits related to lipid metabolism is decomposed in a relatively large Danish twin population, including bivariate analysis to detect possible common genetic factors of the traits. CONCLUSIONS: The heritabilities of apolipoprotein B and E, cholesterol, LDL, and high density lipoprotein (HDL) were significant in the general population, although gender-specific levels and significance were detected. Heritabilities of apolipoprotein A1, triglycerides, and very low density protein (VLDL) were only significant when the population was stratified according to gender.
Udgivelsesdato: 2007-Mar
Udgave nummer1
Sider (fra-til)40-7
Antal sider7
StatusUdgivet - 2007


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