Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Injury-mediated decrease in locomotor performance increases predation risk in schooling fish

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Identifying serotonergic mechanisms underlying the corticolimbic response to threat in humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Association Between Neurological Disorders and Death by Suicide in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cystic fibrosis newborn screening in Denmark: Experience from the first 2 years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • iPSYCH-Broad ASD Group
Vis graf over relationer

There is great interest in the role epigenetic variation induced by non-genetic exposures may play in the context of health and disease. In particular, DNA methylation has previously been shown to be highly dynamic during the earliest stages of development and is influenced by in utero exposures such as maternal smoking and medication. In this study we sought to identify the specific DNA methylation differences in blood associated with prenatal and birth factors, including birth weight, gestational age and maternal smoking. We quantified neonatal methylomic variation in 1263 infants using DNA isolated from a unique collection of archived blood spots taken shortly after birth (mean = 6.08 days; s.d. = 3.24 days). An epigenome-wide association study (EWAS) of gestational age and birth weight identified 4299 and 18 differentially methylated positions (DMPs) respectively, at an experiment-wide significance threshold of p < 1 × 10-7. Our EWAS of maternal smoking during pregnancy identified 110 DMPs in neonatal blood, replicating previously reported genomic loci, including AHRR. Finally, we tested the hypothesis that DNA methylation mediates the relationship between maternal smoking and lower birth weight, finding evidence that methylomic variation at three DMPs may link exposure to outcome. These findings complement an expanding literature on the epigenomic consequences of prenatal exposures and obstetric factors, confirming a link between the maternal environment and gene regulation in neonates. This article is part of the theme issue 'Developing differences: early-life effects and evolutionary medicine'.

OriginalsprogEngelsk
TidsskriftRoyal Society of London. Philosophical Transactions B. Biological Sciences
Vol/bind374
Udgave nummer1770
Sider (fra-til)20180120
ISSN0962-8436
DOI
StatusUdgivet - 15 apr. 2019

ID: 58594661