Vancomycin decreases insulin sensitivity and is associated with alterations in intestinal microbiota and bile acid composition in obese subjects with metabolic syndrome

Anne Vrieze, Carolien Out, Susana Fuentes, Lisanne Jonker, Isaie Reuling, Ruud S Kootte, E van Nood, Frits Holleman, Max Knaapen, Johannes A Romijn, Maarten R Soeters, Ellen E Blaak, Geesje M Dallinga-Thie, Dorien Reijnders, Mariëtte T Ackermans, Mireille J Serlie, Filip K Knop, Jens J Holst, Claude van der Ley, Ido P KemaErwin G Zoetendal, Willem M de Vos, Joost B L Hoekstra, E S Stroes, Albert K Groen, Max Nieuwdorp

    462 Citationer (Scopus)

    Abstract

    Obesity has been associated with changes in the composition and function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters bile acid and glucose metabolism in mice. Hence, we hypothesized that short term administration of oral antibiotics in humans would affect fecal microbiota composition and subsequently bile acid and glucose metabolism.
    OriginalsprogEngelsk
    TidsskriftJournal of Hepatology
    Vol/bind60
    Udgave nummer4
    Sider (fra-til)824-831
    Antal sider8
    ISSN0168-8278
    DOI
    StatusUdgivet - apr. 2014

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