Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Validation of a register-based algorithm for recurrence in rectal cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Outcomes and follow-up programmes in extreme preterm children in Denmark in the EPICE/SHIPS cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Risk of pancreatitis in patients with inflammatory bowel disease - a meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Danish expanded newborn screening is a successful preventive public health programme

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Analgesics use and withdrawal in people with dementia - a register-based Danish study and a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  5. Everolimus as adjunctive treatment in tuberous sclerosis complex-associated epilepsy in children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Associations between blood cultures after surgery for colorectal cancer and long-term oncological outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The clinical implication of the association between hypoxaemia and postoperative troponin I: a reply

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  3. Circumferential Resection Margin After Laparoscopic and Open Rectal Resection: A Nationwide Propensity Score Matched Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

INTRODUCTION: Colorectal cancer is the third most common type of cancer worldwide. Recurrence is an important end-point in colorectal cancer research. This study aimed to validate a previously developed algorithm to determine recurrence after surgery for rectal cancer.

METHODS: Information about a cohort of 500 patients with rectal cancer was retrieved from the Danish Civil Registration System, the Danish National Patient Register and the Danish National Pathology Register. Patients with an ICD-10 code for metastatic disease, chemotherapy or SNOMED code suggesting metastasis were identified as having recurrence. In a previous study, medical records of the same cohort had been reviewed to identify recurrence. Recurrence identified by the algorithm was compared with the previously retrieved information from the medical records using Kappa statistics. The sensitivity and specificity of the algorithm were determined.

RESULTS: Of the 500 patients, 393 were included in the validation analysis. Kappa statistics showed good concordance with a Kappa value (95% confidence interval) of 0.80 (0.72-0.88). The sensitivity and specificity of the algorithm were 88% (77-95%) and 96% (93-98%), respectively.

CONCLUSIONS: The study showed good concordance between the algorithm and medical record information. The algorithm makes it possible to perform large register-based studies of recurrence and disease-free survival in colorectal cancer patients without the need for evaluation of medical records.

FUNDING: none.

TRIAL REGISTRATION: not relevant.

OriginalsprogEngelsk
TidsskriftDanish Medical Journal
Vol/bind65
Udgave nummer10
ISSN1603-9629
StatusUdgivet - okt. 2018

ID: 56360290