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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Vaginal estrogen and association with dementia: A nationwide population-based study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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INTRODUCTION: Use of systemic hormone therapy has been positively associated with development of dementia. Little is known about the dose-dependent effect of vaginal estradiol on dementia risk.

METHODS: We assessed associations between cumulative dose of vaginal estradiol tablets and dementia in a case-control study nested in a nationwide Danish cohort of women aged 50 to 60 years at study initiation, who did not use systemic hormone therapy. Each case was age-matched to 10 female controls.

RESULTS: A total of 4574 dementia cases were matched to 45,740 controls. Cumulative use of vaginal estradiol tablets was not associated with all-cause dementia; adjusted hazard ratio 1.02 (95% confidence interval [CI] 0.89-1.18) for low dose (< 750 mcg), 1.07 (0.94-1.21) for medium dose (750-2000 mcg), and 0.93 (0.84-1.03) for high dose (> 2000 mcg). Similarly, Alzheimer's disease (AD) only was not associated with vaginal estradiol.

DISCUSSION: Exposure to vaginal estradiol tablets was not associated with all-cause dementia or AD only.

OriginalsprogEngelsk
TidsskriftAlzheimer's & dementia : the journal of the Alzheimer's Association
ISSN1552-5260
DOI
StatusE-pub ahead of print - 28 jul. 2021

Bibliografisk note

© 2021 the Alzheimer's Association.

ID: 68136532