Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

Jean-Christophe Meunier, Judith M Gottwein, Michael Houghton, Rodney S Russell, Suzanne U Emerson, Jens Bukh, Robert H Purcell

90 Citationer (Scopus)

Abstract

We detected cross-reactive neutralizing antibodies (NtAb) against hepatitis C virus (HCV) in chimpanzees vaccinated with HCV-1 (genotype 1a) recombinant E1/E2 envelope glycoproteins. Five vaccinated chimpanzees, protected following HCV-1 challenge, were initially studied using the heterologous H77 (genotype 1a) HCVpp assay. All animals had developed NtAb after the second vaccination; 4 animals had reciprocal titers of ≥200 at the time of challenge. Using genotypes 1a-6a HCV pseudoparticles (HCVpp) and cell culture-derived HCV (HCVcc) assays, cross-reactive NtAb were detected against 1a, 4a, 5a, and 6a, with limited reactivity against 2a and 3a. Our study provides encouragement for the development of a recombinant envelope-based vaccine against hepatitis C.
OriginalsprogEngelsk
TidsskriftJournal of Infectious Diseases
Vol/bind204
Udgave nummer8
Sider (fra-til)1186-90
Antal sider5
ISSN0022-1899
DOI
StatusUdgivet - 2011

Fingeraftryk

Dyk ned i forskningsemnerne om 'Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus'. Sammen danner de et unikt fingeraftryk.

Citationsformater