Using rapid diagnostic tests as source of malaria parasite DNA for molecular analyses in the era of declining malaria prevalence

Deus S Ishengoma, Sudi Lwitiho, Rashid A Madebe, Nyagonde Nyagonde, Ola Persson, Lasse Steenbock Vestergaard, Ib C Bygbjerg, Martha M Lemnge, Michael Alifrangis

    37 Citationer (Scopus)

    Abstract

    Malaria prevalence has recently declined markedly in many parts of Tanzania and other sub-Saharan African countries due to scaling-up of control interventions including more efficient treatment regimens (e.g. artemisinin-based combination therapy) and insecticide-treated bed nets. Although continued molecular surveillance of malaria parasites is important to early identify emerging anti-malarial drug resistance, it is becoming increasingly difficult to obtain parasite samples from ongoing studies, such as routine drug efficacy trials. To explore other sources of parasite DNA, this study was conducted to examine if sufficient DNA could be successfully extracted from malaria rapid diagnostic tests (RDTs), used and collected as part of routine case management services in health facilities, and thus forming the basis for molecular analyses, surveillance and quality control (QC) testing of RDTs.
    OriginalsprogEngelsk
    TidsskriftMalaria Journal
    Vol/bind10
    Sider (fra-til)6
    ISSN1475-2875
    DOI
    StatusUdgivet - 1 jan. 2011

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