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Region Hovedstaden - en del af Københavns Universitetshospital
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Using assessment criteria for pesticides to evaluate the endocrine disrupting potential of non-pesticide chemicals: Case butylparaben

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  1. Long-term exposure to low levels of air pollution and mortality adjusting for road traffic noise: A Danish Nurse Cohort study

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  2. Physiologically based kinetic (PBK) modelling and human biomonitoring data for mixture risk assessment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Long-term exposure to air pollution and stroke incidence: A Danish Nurse cohort study

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  1. Impact of psychological stress measured in three different scales on testis function: A cross-sectional study of 1362 young men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Physiologically based kinetic (PBK) modelling and human biomonitoring data for mixture risk assessment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Levels of endocrine-disrupting chemicals are associated with changes in the peri-pubertal epigenome

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  4. Predicting Transdermal Uptake of Phthalates and a Paraben from Cosmetic Cream Using the Measured Fugacity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Regulation of chemicals with endocrine disrupting properties depend on the use of the chemical rather than its intrinsic properties. Within the EU, the only criteria currently in place for identifying an endocrine disrupting chemical (EDC) are those developed for biocidal and plant protection products. We argue that ECHA/EFSA guidance for assessing endocrine disrupting properties of biocidal and plant protection products can be applied to all chemicals independent of their intended use. We have assessed the REACH-registered compound butylparaben (CAS 94-36-8), a preservative used primarily in cosmetics. Based on scientific evidence of adverse reproductive effects and endocrine activity, the open literature suggest that butylparaben is an EDC. By applying the ECHA/EFSA guidance for pesticides and biocides, we identify butylparaben as a compound with endocrine disrupting properties. Even though available data is markedly different from that for biocides and pesticides, it was possible to reach this conclusion. More generally, we propose that the ECHA/EFSA guidance can and should be used for identification of EDC regardless of their intended application.

OriginalsprogEngelsk
TidsskriftEnvironment International
Vol/bind144
Sider (fra-til)105996
ISSN0160-4120
DOI
StatusUdgivet - nov. 2020

Bibliografisk note

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

ID: 60688301