Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring

Kamilla Westarp Zornhagen; Malene Clausen; Anders E Hansen; Ian Law; Fintan McEvoy; Svend A Engelholm; Andreas Kjær; Annemarie T Kristensen

doi:10.3390/diagnostics5030372

Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring

Kamilla Westarp Zornhagen
, Malene Clausen
, Anders E Hansen
, Ian Law
, Fintan McEvoy
, Svend A Engelholm
, Andreas Kjær
, Annemarie T Kristensen

Afdeling for Klinisk Fysiologi og Nuklearmedicin DIA

3 Citationer (Scopus)

Abstract

Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using (18)F-FDG, (64)Cu-ATSM, and (18)F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in (18)F-FDG and (18)F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.

Originalsprog	Engelsk
Tidsskrift	Diagnostics
Vol/bind	5
Udgave nummer	3
Sider (fra-til)	372-82
Antal sider	11
ISSN	2075-4418
DOI	https://doi.org/10.3390/diagnostics5030372
Status	Udgivet - 2015

Adgang til dokumentet

10.3390/diagnostics5030372

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Citationsformater

Zornhagen, K. W., Clausen, M., Hansen, A. E., Law, I., McEvoy, F., Engelholm, S. A., Kjær, A., & Kristensen, A. T. (2015). Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring. Diagnostics, 5(3), 372-82. https://doi.org/10.3390/diagnostics5030372

Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring. / Zornhagen, Kamilla Westarp; Clausen, Malene; Hansen, Anders E et al.
I: Diagnostics, Bind 5, Nr. 3, 2015, s. 372-82.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Zornhagen, KW, Clausen, M, Hansen, AE, Law, I, McEvoy, F, Engelholm, SA, Kjær, A & Kristensen, AT 2015, 'Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring', Diagnostics, bind 5, nr. 3, s. 372-82. https://doi.org/10.3390/diagnostics5030372

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title = "Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring",

abstract = "Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using (18)F-FDG, (64)Cu-ATSM, and (18)F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in (18)F-FDG and (18)F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.",

author = "Zornhagen, \{Kamilla Westarp\} and Malene Clausen and Hansen, \{Anders E\} and Ian Law and Fintan McEvoy and Engelholm, \{Svend A\} and Andreas Kj{\ae}r and Kristensen, \{Annemarie T\}",

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doi = "10.3390/diagnostics5030372",

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T2 - The Importance of Individualized Treatment Planning and Monitoring

AU - Zornhagen, Kamilla Westarp

AU - Clausen, Malene

AU - Hansen, Anders E

AU - Law, Ian

AU - McEvoy, Fintan

AU - Engelholm, Svend A

AU - Kjær, Andreas

AU - Kristensen, Annemarie T

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N2 - Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using (18)F-FDG, (64)Cu-ATSM, and (18)F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in (18)F-FDG and (18)F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.

AB - Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using (18)F-FDG, (64)Cu-ATSM, and (18)F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in (18)F-FDG and (18)F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.

U2 - 10.3390/diagnostics5030372

DO - 10.3390/diagnostics5030372

M3 - Journal article

C2 - 26854160

SN - 2075-4418

VL - 5

SP - 372

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JO - Diagnostics

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