TY - JOUR
T1 - Use of fertility drugs and risk of ovarian cancer
T2 - Danish Population Based Cohort Study
AU - Jensen, Allan
AU - Sharif, Heidi
AU - Frederiksen, Kirsten
AU - Kjaer, Susanne Krüger
PY - 2009/2/5
Y1 - 2009/2/5
N2 - OBJECTIVE: To examine the effects of fertility drugs on overall risk of ovarian cancer using data from a large cohort of infertile women.DESIGN: Population based cohort study.SETTING: Danish hospitals and private fertility clinics.PARTICIPANTS: 54,362 women with infertility problems referred to all Danish fertility clinics during 1963-98. The median age at first evaluation of infertility was 30 years (range 16-55 years), and the median age at the end of follow-up was 47 (range 18-81) years. Included in the analysis were 156 women with invasive epithelial ovarian cancer (cases) and 1241 subcohort members identified in the cohort during follow-up in 2006.MAIN OUTCOME MEASURE: Effect of four groups of fertility drugs (gonadotrophins, clomifene citrate, human chorionic gonadotrophin, and gonadotrophin releasing hormone) on overall risk of ovarian cancer after adjustment for potential confounding factors.RESULTS: Analyses within cohort showed no overall increased risk of ovarian cancer after any use of gonadotrophins (rate ratio 0.83, 95% confidence interval 0.50 to 1.37), clomifene (1.14, 0.79 to 1.64), human chorionic gonadotrophin (0.89, 0.62 to 1.29), or gonadotrophin releasing hormone (0.80, 0.42 to 1.51). Furthermore, no associations were found between all four groups of fertility drugs and number of cycles of use, length of follow-up, or parity.CONCLUSION: No convincing association was found between use of fertility drugs and risk of ovarian cancer.
AB - OBJECTIVE: To examine the effects of fertility drugs on overall risk of ovarian cancer using data from a large cohort of infertile women.DESIGN: Population based cohort study.SETTING: Danish hospitals and private fertility clinics.PARTICIPANTS: 54,362 women with infertility problems referred to all Danish fertility clinics during 1963-98. The median age at first evaluation of infertility was 30 years (range 16-55 years), and the median age at the end of follow-up was 47 (range 18-81) years. Included in the analysis were 156 women with invasive epithelial ovarian cancer (cases) and 1241 subcohort members identified in the cohort during follow-up in 2006.MAIN OUTCOME MEASURE: Effect of four groups of fertility drugs (gonadotrophins, clomifene citrate, human chorionic gonadotrophin, and gonadotrophin releasing hormone) on overall risk of ovarian cancer after adjustment for potential confounding factors.RESULTS: Analyses within cohort showed no overall increased risk of ovarian cancer after any use of gonadotrophins (rate ratio 0.83, 95% confidence interval 0.50 to 1.37), clomifene (1.14, 0.79 to 1.64), human chorionic gonadotrophin (0.89, 0.62 to 1.29), or gonadotrophin releasing hormone (0.80, 0.42 to 1.51). Furthermore, no associations were found between all four groups of fertility drugs and number of cycles of use, length of follow-up, or parity.CONCLUSION: No convincing association was found between use of fertility drugs and risk of ovarian cancer.
KW - Adolescent
KW - Adult
KW - Age of Onset
KW - Aged
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Female
KW - Fertility Agents/adverse effects
KW - Humans
KW - Infertility, Female/drug therapy
KW - Maternal Age
KW - Middle Aged
KW - Ovarian Neoplasms/chemically induced
KW - Parity
KW - Pregnancy
KW - Risk Factors
KW - Young Adult
U2 - 10.1136/bmj.b249
DO - 10.1136/bmj.b249
M3 - Journal article
C2 - 19196744
SN - 1756-1833
VL - 338
SP - b249
JO - BMJ (Clinical research ed.)
JF - BMJ (Clinical research ed.)
ER -