Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Use of antidepressants and endometrial-cancer risk: a nationwide nested case-control study

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review


  1. Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Cohort Profile: The Copenhagen Baby Heart Study (CBHS)

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Duration of diabetes-related complications and mortality in type 1 diabetes: a national cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

BACKGROUND: Preclinical studies have suggested that antidepressant drugs may possess antineoplastic properties. In a nationwide case-control study, we examined the association between use of antidepressants and endometrial-cancer risk with a particular focus on selective serotonin reuptake inhibitors (SSRIs).

METHODS: From the Danish Cancer Registry, we identified all women with a histologically verified diagnosis of endometrial cancer between 2000 and 2016, and, for each woman, 15 age-matched controls. We obtained information on use of SSRIs, tricyclic antidepressants (TCAs) and other antidepressants based on records of filled prescriptions from the National Prescription Register. Using conditional logistic regression, we calculated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between use of antidepressants and endometrial-cancer risk compared with non-use. In active comparator analyses, SSRI use was compared with TCA use.

RESULTS: The study population comprised 8164 cases and 122 432 controls. Compared with non-use, SSRI use was associated with an OR of 0.88 (95% CI 0.82-0.96) for endometrial cancer, whereas the association with TCA use was close to unity (OR 1.05, 95% CI 0.90-1.22). Use of other antidepressants yielded an OR of 0.86 (95% CI 0.71-1.03). We observed no apparent trends in associations according to cumulative amount. The inverse association with SSRI use persisted when compared with TCA use (OR 0.81, 95% CI 0.66-0.99).

CONCLUSIONS: Use of SSRIs was associated with a decreased risk of endometrial cancer, whereas no inverse association appeared with use of TCAs. The antineoplastic potential of SSRIs should be investigated in future studies.

TidsskriftInternational Journal of Epidemiology
Udgave nummer3
Sider (fra-til)799-806
Antal sider8
StatusUdgivet - 13 jun. 2022

Bibliografisk note

© The Author(s) 2021; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

ID: 73985636