Use of Antibiotics during Pregnancy Increases the Risk of Asthma in Early Childhood

Lone Graff Stensballe, Jacob Simonsen, Signe M Jensen, Klaus Bønnelykke, Hans Bisgaard

210 Citationer (Scopus)

Abstract

OBJECTIVES: To investigate the hypothesis that mother's use of antibiotics in pregnancy could influence asthma and eczema in early life. STUDY DESIGN: Subjects were included from the Copenhagen Prospective Study on Asthma in Childhood cohort of children born of mothers with asthma (N = 411). Severe asthma exacerbations and eczema were diagnosed by research unit physicians. Replication was sought in children from the Danish National Birth Cohort (N = 30 675). Asthma outcomes were hospitalization and use of inhaled corticosteroids. Eczema was defined by an algorithm developed from cases of clinically verified eczema. All children were followed to age 5 years in a cohort study design. RESULTS: The Copenhagen Prospective Study on Asthma in Childhood data showed increased risk of asthma exacerbation (hazard ratio 1.98 [95% CI 1.08-3.63]) if mothers had used antibiotics during third trimester. The Danish National Birth Cohort confirmed increased risk of asthma hospitalization (hazard ratio 1.17 [1.00-1.36]), and inhaled corticosteroids (1.18 [1.10-1.27]) in the children if mothers used antibiotics any time during pregnancy. In the subgroup of mothers using antibiotics for nonrespiratory infection, the children also had increased risk of asthma. CONCLUSION: We found increased risk of asthma associated with maternal antibiotic use in a clinical study of a birth cohort with increased risk of asthma and replicated this finding in an unselected national birth cohort, and in a subgroup using antibiotics for nonrespiratory infections. This supports a role for bacterial ecology in pre- or perinatal life for the development of asthma.
OriginalsprogEngelsk
TidsskriftJournal of Pediatrics
Vol/bind162
Udgave nummer4
Sider (fra-til)832-838
Antal sider6
ISSN0022-3476
DOI
StatusUdgivet - apr. 2013

Fingeraftryk

Dyk ned i forskningsemnerne om 'Use of Antibiotics during Pregnancy Increases the Risk of Asthma in Early Childhood'. Sammen danner de et unikt fingeraftryk.

Citationsformater