TY - JOUR
T1 - Use of 5-Aminolevulinic Acid and Daylight Photodynamic Therapy for the Treatment of Actinic Keratoses
AU - Shive, Melissa L
AU - Coakley, Brandon J
AU - Bierman, Dina F
AU - Serowka Lane, Kathryn L
AU - Wiegell, Stine R
AU - Haedersdal, Merete
AU - Zachary, Christopher B
PY - 2019/4
Y1 - 2019/4
N2 - BACKGROUND: Photodynamic therapy (PDT) is an effective modality for the treatment of actinic keratoses (AKs). The use of methyl aminolevulinate with daylight PDT (D-PDT) has quickly gained popularity internationally because of its tolerability and high levels of safety and efficacy. However, there is a paucity of studies on the use of D-PDT with 5-aminolevulinic acid (ALA).OBJECTIVE: To study the safety and efficacy of D-PDT in treating AKs on the face and scalp using ALA.MATERIALS AND METHODS: Thirty patients were recruited for this prospective, uncontrolled study. Patients were treated with topical ALA on either the scalp or face, incubated for 30 minutes, and then sat at home in a shady area for 2 hours. Weather conditions, lux measurements, and AK counts at 3 and 6 months were measured.RESULTS: Daylight PDT led to a median of 75% reduction in AK count at 6 months, with no significant adverse effects. Ninety-six percentage of patients were either moderately or very satisfied with the treatment, and the median peak pain score during treatment was 1. There was no correlation between weather or average lux received during treatment and 6-month outcomes.CONCLUSION: Daylight PDT with ALA is a safe and effective treatment modality for AKs on the head.
AB - BACKGROUND: Photodynamic therapy (PDT) is an effective modality for the treatment of actinic keratoses (AKs). The use of methyl aminolevulinate with daylight PDT (D-PDT) has quickly gained popularity internationally because of its tolerability and high levels of safety and efficacy. However, there is a paucity of studies on the use of D-PDT with 5-aminolevulinic acid (ALA).OBJECTIVE: To study the safety and efficacy of D-PDT in treating AKs on the face and scalp using ALA.MATERIALS AND METHODS: Thirty patients were recruited for this prospective, uncontrolled study. Patients were treated with topical ALA on either the scalp or face, incubated for 30 minutes, and then sat at home in a shady area for 2 hours. Weather conditions, lux measurements, and AK counts at 3 and 6 months were measured.RESULTS: Daylight PDT led to a median of 75% reduction in AK count at 6 months, with no significant adverse effects. Ninety-six percentage of patients were either moderately or very satisfied with the treatment, and the median peak pain score during treatment was 1. There was no correlation between weather or average lux received during treatment and 6-month outcomes.CONCLUSION: Daylight PDT with ALA is a safe and effective treatment modality for AKs on the head.
KW - Aminolevulinic Acid/administration & dosage
KW - Facial Dermatoses/drug therapy
KW - Humans
KW - Keratosis, Actinic/drug therapy
KW - Photochemotherapy/methods
KW - Photosensitizing Agents/administration & dosage
KW - Scalp Dermatoses/drug therapy
KW - Sunlight
KW - Treatment Outcome
U2 - 10.1097/DSS.0000000000001771
DO - 10.1097/DSS.0000000000001771
M3 - Journal article
C2 - 30807390
SN - 1076-0512
VL - 45
SP - 529
EP - 535
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 4
ER -