Urinary excretion of unconjugated and conjugated 3,5-diiodothyronine

E Hommel, J Faber, C Kirkegaard, K Siersbaek-Nielsen, T Friis

Abstract

A radioimmunoassay for the estimation of 3,5-diiodothyronine (3,5-T2) in human urine has been established. The urinary excretion of both glucuronide and sulfate conjugates of 3,5-T2 were estimated after enzymatic deconjugation. In 19 healthy controls the median excretion of unconjugated 3,5-T2 was 276 pmol/d, whereas the median excretion of glucuronidated and sulfated 3,5-T2 in 7 healthy subjects was 448 and 451 pmol/d, respectively. The median excretion of 154 pmol/d in 9 hypothyroid patients did not differ from that found in controls. In contrast 12 patients with hyperthyroidism had an enhanced excretion, 1312 pmol/d (P less than 0.01). Compared with previous data on the daily degradation of 3,5-T2, it is concluded that approximately one-sixth of degradated 3,5-T2 is excreted in the urine.

OriginalsprogEngelsk
TidsskriftHormone and Metabolic Research
Vol/bind17
Udgave nummer2
Sider (fra-til)90-2
Antal sider3
ISSN0018-5043
DOI
StatusUdgivet - feb. 1985
Udgivet eksterntJa

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