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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Upper Extremity DVT versus Lower Extremity DVT: Perspectives from the GARFIELD-VTE Registry

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Smoking is Associated with Increased Risk of Major Bleeding: A Prospective Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Assessment of Outcomes Among Patients With Venous Thromboembolism With and Without Chronic Kidney Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Comparative effectiveness of oral anticoagulants in venous thromboembolism: GARFIELD-VTE

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Anticoagulation therapy patterns for acute treatment of venous thromboembolism in GARFIELD-VTE patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Walter Ageno
  • Sylvia Haas
  • Jeffrey I Weitz
  • Samuel Z Goldhaber
  • Alexander G G Turpie
  • Shinya Goto
  • Pantep Angchaisuksiri
  • Joern Dalsgaard Nielsen
  • Gloria Kayani
  • Alfredo E Farjat
  • Audrey Zaghdoun
  • Sebastian Schellong
  • Henri Bounameaux
  • Lorenzo G Mantovani
  • Paolo Prandoni
  • Harald Darius
  • Ajay K Kakkar
Vis graf over relationer

Upper extremity deep vein thrombosis (UEDVT) is less common than lower extremity DVT (LEDVT) and consequently less well characterized. This study compared clinical characteristics and 1-year outcomes between 438 UEDVT patients and 7,602 LEDVT patients recruited in the GARFIELD-VTE registry. UEDVT patients were significantly more likely to have a central venous catheter than those with LEDVT (11.5% vs. 0.5%; p < 0.0001), and had a higher rate of active cancer (16.2%) or recent hospitalization (19.4%) compared with LEDVT patients (8.7% and 11.2%, respectively). Nearly all patients with UEDVT and LEDVT were initiated on anticoagulant therapy, which was a direct oral anticoagulant in one-third individuals in both groups. At 3, 6, and 12 months, the proportion of UEDVT and LEDVT patients who were receiving anticoagulant therapy was 82.6 and 87.4%, 66.0 and 72.6%, and 45.7 and 54.6%, respectively. In the UEDVT and LEDVT groups, VTE recurrence rate was 4.0 (95% confidence interval [CI], 2.4-6.7) and 5.5 (95% CI, 4.9-6.1) per 100 person-years, respectively; major bleed was noted in 1.3 (95% CI, 0.6-3.2) and 1.6 (95% CI, 1.3-1.9) per 100 person-years and all-cause mortality in 9.7 (95% CI, 7.1-13.4) and 6.7 (95% CI, 6.1-7.3) per 100 person-years, respectively. Hence, risk of recurrence was similar in the two groups whereas all-cause mortality was significantly higher in the UEDVT group than the LEDVT group (p = 0.0338). This latter finding was likely due to the high prevalence of cancer in the UEDVT group.

OriginalsprogEngelsk
TidsskriftThrombosis and Haemostasis
Vol/bind119
Udgave nummer8
Sider (fra-til)1365-1372
Antal sider8
ISSN0340-6245
DOI
StatusUdgivet - aug. 2019

Bibliografisk note

Georg Thieme Verlag KG Stuttgart · New York.

ID: 61882669