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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Unsulfated cholecystokinin: An overlooked hormone?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Natriuretic peptides and cerebral hemodynamics

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  3. Adropin: a new regulatory peptide in cardiovascular endocrinology

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  4. Cardiac C-type natriuretic peptide gene expression and plasma concentrations in neonatal piglets

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  5. Gut hormones - Team workers or solo trippers?

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  1. Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Limited diagnostic utility of Chromogranin A measurements in workup of neuroendocrine tumors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Oral D/L-3-Hydroxybutyrate stimulates cholecystokinin and insulin secretion and slows gastric emptying in healthy males

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  4. Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy

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Vis graf over relationer
Tyrosyl O-sulfation is a common posttranslational derivatization of proteins that may also modify regulatory peptides. Among these are members of the cholecystokinin (CCK)/gastrin family. While sulfation of gastrin peptides is without effect on the bioactivity, O-sulfation is crucial for the cholecystokinetic activity (i.e. gallbladder emptying) of CCK peptides. Accordingly, the purification of CCK as a sulfated peptide was originally monitored by its gallbladder emptying effect. Since then, the dogma has prevailed that CCK peptides are always sulfated. The dogma is correct in a semantic context since the gallbladder expresses only the CCK-A receptor that requires sulfation of the ligand. CCK peptides, however, are also ligands for the CCK-B receptors that do not require ligand sulfation. Consequently, unsulfated CCK peptides may act via CCK-B receptors. Since in vivo occurrence of unsulfated products of proCCK with an intact α-amidated C-terminal tetrapeptide sequence (-Trp-Met-Asp-PheNH(2)) has been reported, it is likely that unsulfated CCK peptides constitute a separate hormone system that acts via CCK-B receptors. This review discusses the occurrence, molecular forms, and possible physiological as well as pathophysiological significance of unsulfated CCK peptides.
OriginalsprogEngelsk
TidsskriftRegulatory Peptides
Vol/bind173
Udgave nummer1-3
Sider (fra-til)1-5
Antal sider5
ISSN0167-0115
DOI
StatusUdgivet - 2012

ID: 36789524