Unmet Medical Needs in Metastatic Lung and Digestive Neuroendocrine Neoplasms

Jaume Capdevila; Lisa Bodei; Philippa Davies; Vera Gorbounova; Robert T Jensen; Ulrich P Knigge; Guenter J Krejs; Eric Krenning; Juan Manuel O'Connor; Marc Peeters; Guido Rindi; Ramon Salazar; Marie-Pierre Vullierme; Marianne E Pavel; ENETS 2016 Munich Advisory Board Participants

doi:10.1159/000493319

Unmet Medical Needs in Metastatic Lung and Digestive Neuroendocrine Neoplasms

Jaume Capdevila, Lisa Bodei, Philippa Davies, Vera Gorbounova, Robert T Jensen, Ulrich P Knigge, Guenter J Krejs, Eric Krenning, Juan Manuel O'Connor, Marc Peeters, Guido Rindi, Ramon Salazar, Marie-Pierre Vullierme, Marianne E Pavel, ENETS 2016 Munich Advisory Board Participants

8 Citationer (Scopus)

Abstract

Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.

Originalsprog	Engelsk
Tidsskrift	Neuroendocrinology
Vol/bind	108
Udgave nummer	1
Sider (fra-til)	18-25
Antal sider	8
ISSN	0028-3835
DOI	https://doi.org/10.1159/000493319
Status	Udgivet - 1 jan. 2019

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10.1159/000493319

Citationsformater

Capdevila, J., Bodei, L., Davies, P., Gorbounova, V., Jensen, R. T., Knigge, U. P., Krejs, G. J., Krenning, E., O'Connor, J. M., Peeters, M., Rindi, G., Salazar, R., Vullierme, M.-P., Pavel, M. E., & ENETS 2016 Munich Advisory Board Participants (2019). Unmet Medical Needs in Metastatic Lung and Digestive Neuroendocrine Neoplasms. Neuroendocrinology, 108(1), 18-25. https://doi.org/10.1159/000493319

Capdevila, J, Bodei, L, Davies, P, Gorbounova, V, Jensen, RT, Knigge, UP, Krejs, GJ, Krenning, E, O'Connor, JM, Peeters, M, Rindi, G, Salazar, R, Vullierme, M-P, Pavel, ME & ENETS 2016 Munich Advisory Board Participants 2019, 'Unmet Medical Needs in Metastatic Lung and Digestive Neuroendocrine Neoplasms', Neuroendocrinology, bind 108, nr. 1, s. 18-25. https://doi.org/10.1159/000493319

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abstract = "Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.",

keywords = "Biomarkers, Imaging, Metastasis, Neuroendocrine neoplasms, Therapy, Unmet medical needs, Digestive System Neoplasms/diagnosis, Humans, Lung Neoplasms/diagnosis, Neuroendocrine Tumors/diagnostic imaging, Biomedical Research/trends, Drug Development, Biomarkers, Tumor/metabolism",

author = "Jaume Capdevila and Lisa Bodei and Philippa Davies and Vera Gorbounova and Jensen, {Robert T} and Knigge, {Ulrich P} and Krejs, {Guenter J} and Eric Krenning and O'Connor, {Juan Manuel} and Marc Peeters and Guido Rindi and Ramon Salazar and Marie-Pierre Vullierme and Pavel, {Marianne E} and ENETS 2016 Munich Advisory Board Participants",

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AU - Jensen, Robert T

AU - Knigge, Ulrich P

AU - Krejs, Guenter J

AU - Krenning, Eric

AU - O'Connor, Juan Manuel

AU - Peeters, Marc

AU - Rindi, Guido

AU - Salazar, Ramon

AU - Vullierme, Marie-Pierre

AU - Pavel, Marianne E

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N2 - Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.

AB - Unmet medical needs are not infrequent in oncology, and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade, and, currently, a new WHO classification is being implemented and several treatment options are available in the metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered, and decisions in our daily clinical practice should be made with limited evidence. In the 2016 meeting of the advisory board of the European Neuroendocrine Tumor Society (ENETS), the main unmet medical needs in the metastatic NENs setting were deeply discussed, and several proposals to try to solve them are presented in this article, including biomarkers, imaging, and therapy.

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KW - Metastasis

KW - Neuroendocrine neoplasms

KW - Therapy

KW - Unmet medical needs

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KW - Lung Neoplasms/diagnosis

KW - Neuroendocrine Tumors/diagnostic imaging

KW - Biomedical Research/trends

KW - Drug Development

KW - Biomarkers, Tumor/metabolism

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JO - Neuroendocrinology

JF - Neuroendocrinology

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Unmet Medical Needs in Metastatic Lung and Digestive Neuroendocrine Neoplasms

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