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Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory

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  • M Postans
  • G D Parker
  • H Lundell
  • M Ptito
  • K Hamandi
  • W P Gray
  • J P Aggleton
  • T B Dyrby
  • D K Jones
  • M Winter
Vis graf over relationer

The dorsal hippocampal commissure (DHC) is a white matter tract that provides interhemispheric connections between temporal lobe brain regions. Despite the importance of these regions for learning and memory, there is scant evidence of a role for the DHC in successful memory performance. We used diffusion-weighted magnetic resonance imaging (DW-MRI) and white matter tractography to reconstruct the DHC in both humans (in vivo) and nonhuman primates (ex vivo). Across species, our findings demonstrate a close consistency between the known anatomy and tract reconstructions of the DHC. Anterograde tract-tracer techniques also highlighted the parahippocampal origins of DHC fibers in nonhuman primates. Finally, we derived diffusion tensor MRI metrics from the DHC in a large sample of human subjects to investigate whether interindividual variation in DHC microstructure is predictive of memory performance. The mean diffusivity of the DHC correlated with performance in a standardized recognition memory task, an effect that was not reproduced in a comparison commissure tract-the anterior commissure. These findings highlight a potential role for the DHC in recognition memory, and our tract reconstruction approach has the potential to generate further novel insights into the role of this previously understudied white matter tract in both health and disease.

OriginalsprogEngelsk
Artikelnummerbhz143
TidsskriftCerebral Cortex
Vol/bind30
Udgave nummer3
Sider (fra-til)1001-1015
Antal sider15
ISSN1047-3211
DOI
StatusUdgivet - 14 mar. 2020

Bibliografisk note

© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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