Abstract
SETTING: In 10 healthy subjects, the influence of acute alcohol intake on the pharmacokinetics of isoniazid (INH) was studied.
OBJECTIVE: To test the hypothesis that alcohol increases the conversion of INH by acetylation into its metabolite acetylisoniazid.
DESIGN: In a crossover design, an oral dose of 300 mg INH was administered on 2 separate days, 14 days apart, with or without alcohol to a serum alcohol of about 21 mmol/l (1 g/l) maintained for 12 h.
RESULTS: Neither the metabolism of INH nor that of acetylisoniazid was changed by acute alcohol intake.
CONCLUSION: Acute alcohol intake has no impact on the conversion of INH to its metabolite acetylisoniazid, which is catalysed by the enzyme N-acetyltranferase. Accordingly, a metabolic effect of acute alcohol intake on INH metabolism probably contributes little to the therapeutic failure of anti-tuberculosis treatment among alcoholics.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease |
| Vol/bind | 8 |
| Udgave nummer | 11 |
| Sider (fra-til) | 1373-6 |
| Antal sider | 4 |
| ISSN | 1027-3719 |
| Status | Udgivet - nov. 2004 |