Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Unaffected twins discordant for affective disorders show changes in anterior callosal white matter microstructure

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Trajectory of cognitive functions in bipolar disorder: for better or worse?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Incidence of suicidal behaviour and violent crime following antidepressant medication: a Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Response to comment on Osler et al: misinterpretation of pre- and post differences invalidate the authors' conclusion

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  4. Societal costs of Borderline Personality Disorders: a matched-controlled nationwide study of patients and spouses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Meta-analysis of antidepressant effects of anti-inflammatory drugs-reply

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  1. Cerebellar - premotor cortex interactions underlying visuomotor adaptation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Accurate and robust whole-head segmentation from magnetic resonance images for individualized head modeling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Maintenance of muscle strength following a one-year resistance training program in older adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Antihypertensive Drugs and Risk of Depression: A Nationwide Population-Based Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: The neurobiological mechanisms mediating an increased risk to develop affective disorders remain poorly understood. In a group of individuals with a family history of major depressive (MDD) or bipolar disorder (BD), we investigated the microstructural properties of white matter fiber tracts, that is, cingulum bundle, uncinate fasciculus, anterior limb of the internal capsule, and corpus callosum, that facilitate the communication between brain regions implicated in affective disorders.

METHOD: Eighty-nine healthy mono- or dizygotic twins with a co-twin diagnosed with MDD or BD (high-risk) and 57 healthy twins with a co-twin with no familial history of affective disorders (low-risk) were included in a diffusion tensor imaging study.

RESULT: The high-risk group showed decreased fractional anisotropy (FA), a measure of water diffusion directionality, and increased radial diffusivity in the anterior region of corpus callosum compared to the low-risk group. This abnormality was not associated with zygosity or type of depressive disorder of co-twin.

CONCLUSION: The observed decreased anterior callosal fiber FA in the high-risk group may be indicative of a compromised interhemispheric communication between left and right frontal regions critically involved in mood regulation. Reduced anterior callosal FA may act as a vulnerability marker for affective disorders in individuals at familial risk.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind134
Udgave nummer5
Sider (fra-til)441-451
Antal sider11
ISSN0001-690X
DOI
StatusUdgivet - sep. 2016

ID: 49037134