Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: Neuromodulation of the Femoral Nerve for Postoperative Analgesia Following Ambulatory Anterior Cruciate Ligament Reconstruction: A Proof of Concept Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Transcutaneous Vagus Nerve Stimulation in Patients With Severe Traumatic Brain Injury: A Feasibility Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Sacral Neuromodulation: Standardized Electrode Placement Technique

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Stretch reflex regulation in healthy subjects and patients with spasticity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Brian M Ilfeld
  • Engy T Said
  • John J Finneran
  • Jacklynn F Sztain
  • Wendy B Abramson
  • Rodney A Gabriel
  • Bahareh Khatibi
  • Matthew W Swisher
  • Pia Jaeger
  • Dana C Covey
  • Catherine M Robertson
Vis graf over relationer

OBJECTIVES: The purpose of this prospective proof of concept study was to investigate the feasibility of using percutaneous peripheral nerve stimulation of the femoral nerve to treat pain in the immediate postoperative period following ambulatory anterior cruciate ligament reconstruction with a patellar autograft.

MATERIALS AND METHODS: Preoperatively, an electrical lead (SPRINT, SPR Therapeutics, Inc., Cleveland, OH, USA) was percutaneously implanted with ultrasound guidance anterior to the femoral nerve caudad to the inguinal crease. Within the recovery room, subjects received 5 min of either stimulation or sham in a randomized, double-masked fashion followed by a 5-min crossover period, and then continuous active stimulation until lead removal postoperative Day 14-28. Statistics were not applied to the data due to the small sample size of this feasibility study.

RESULTS: During the initial 5-min treatment period, subjects randomized to stimulation (n = 5) experienced a slight downward trajectory (decrease of 7%) in their pain over the 5 min of treatment, while those receiving sham (n = 5) reported a slight upward trajectory (increase of 4%) until their subsequent 5-min stimulation crossover, during which time they also experienced a slight downward trajectory (decrease of 11% from baseline). A majority of subjects (80%) used a continuous adductor canal nerve block for rescue analgesia (in addition to stimulation) during postoperative Days 1-3, after which the median resting and dynamic pain scores remained equal or less than 1.5 on the numeric rating scale, respectively, and the median daily opioid consumption was less than 1.0 tablet.

CONCLUSIONS: This proof of concept study demonstrates that percutaneous femoral nerve stimulation is feasible for ambulatory knee surgery; and suggests that this modality may be effective in providing analgesia and decreasing opioid requirements following anterior cruciate ligament reconstruction. NCT02898103.

Udgave nummer5
Sider (fra-til)621-629
Antal sider9
StatusUdgivet - jul. 2019

ID: 56763496