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Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Correction to: Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The changing faces of migraine

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. Shaping the future of migraine targeting Calcitonin-Gene-Related-Peptide with the Disease-Modifying Migraine Drugs (DMMDs)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Correction to: Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The changing faces of migraine

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. Effect of hypoxia on BOLD fMRI response and total cerebral blood flow in migraine with aura patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Hemodynamic provocation with acetazolamide shows impaired cerebrovascular reserve in adults with sickle cell disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Sildenafil and calcitonin gene-related peptide both dilate the intradural segments of the middle meningeal artery measured with 3.0 tesla (T) MR angiography. Here we hypothesized that an increase in field strength to 7.0 T and concomitant enhanced voxel resolution would lower variance in measurements of dilation in the intradural middle meningeal artery.

METHODS: Five subjects completed two sessions at respectively 3.0 T and 7.0 T. Each session comprised MR angiography scans once before and twice after administration of sildenafil, calcitonin gene-related peptide or placebo in a three-way, crossover, double-blind, placebo-controlled design.

RESULTS: Standard deviations of arterial circumference revealed no difference between 3.0 T and 7.0 T measurements (p = 0.379). We found a decrease in standard deviation from our original angiography analysis software (QMra) to a newer (LAVA) software package (p < 0.001). Furthermore, we found that the dilation after sildenafil and calcitonin gene-related peptide were comparable between 3.0 T and 7.0 T.

CONCLUSIONS: Our findings suggest no gain from the increase in voxel resolution but cemented dilatory findings from earlier. The implemented software update improved variance in circumference measurements in the intradural middle meningeal artery, which should be exploited in future studies.

TRIAL REGISTRATION: The study is part of a parent study, which is registered at ClinicalTrials.gov ( NCT03143465 ).

OriginalsprogEngelsk
TidsskriftThe Journal of Headache and Pain Online
Vol/bind20
Udgave nummer1
Sider (fra-til)48
Antal sider1
ISSN1129-2377
DOI
StatusUdgivet - 6 maj 2019

ID: 57103215