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Region Hovedstaden - en del af Københavns Universitetshospital
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Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016: A Case Series and Epidemiologic Overview

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. LISTERIA MENINGITIS IN DANISH CHILDREN 2000-2017: A Rare Event Even in a Country With High Rates of Invasive Listeriosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pediatric Candidemia Epidemiology and Morbidities: A Nationwide Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Streptococcal Infections and Exacerbations in PANDAS: A Systematic Review and Meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Borderline-Positive Quantiferon in Children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Current practices for respiratory syncytial virus surveillance across the EU/EEA Member States, 2017

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effectiveness of maternal immunization with trivalent inactivated influenza vaccine in pregnant women and their infants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Taking gastro-surveillance into the 21st century

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Characterisation of HIV-1 transmission clusters and drug-resistant mutations in Denmark, 2004 to 2016

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Enterovirus-D68 (EV-D68) is a respiratory virus within the genus Enterovirus and the family of Picornaviridae. Genetically, it is closely related to rhinovirus that replicates in the respiratory tract and causes respiratory disease. Since 2014, EV-D68 has been associated with the neurologic syndrome of acute flaccid myelitis (AFM).

METHODS: In October 2016, questionnaires were sent out to a European network including 66 virologists and clinicians, to develop an inventory of EV-D68-associated AFM cases in Europe. Clinical and virologic information of case patients was requested. In addition, epidemiologic information on EV testing was collected for the period between March and October 2016.

RESULTS: Twenty-nine cases of EV-D68-associated AFM were identified, from 12 different European countries. Five originated from France, 5 from Scotland and 3 each from Sweden, Norway and Spain. Twenty-six were children (median age 3.8 years), 3 were adults. EV-D68 was detected in respiratory materials (n = 27), feces (n = 8) and/or cerebrospinal fluid (n = 2). Common clinical features were asymmetric flaccid limb weakness, cranial nerve deficits and bulbar symptoms. On magnetic resonance imaging, typical findings were hyperintensity of the central cord and/or brainstem; low motor amplitudes with normal conduction velocities were seen on electromyography. Full clinical recovery was rare (n = 3), and 2 patients died. The epidemiologic data from 16 European laboratories showed that of all EV-D68-positive samples, 99% was detected in a respiratory specimen.

CONCLUSIONS: For 2016, 29 EV-D68-related AFM cases were identified in mostly Western Europe. This is likely an underestimation, because case identification is dependent on awareness among clinicians, adequate viral diagnostics on respiratory samples and the capability of laboratories to type EVs.

OriginalsprogEngelsk
TidsskriftThe Pediatric infectious disease journal
Vol/bind38
Udgave nummer1
Sider (fra-til)16-21
Antal sider6
ISSN0891-3668
DOI
StatusUdgivet - jan. 2019

ID: 56445808