Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Benjamin F Voight; Laura J Scott; Valgerdur Steinthorsdottir; Andrew P Morris; Christian Dina; Ryan P Welch; Eleftheria Zeggini; Cornelia Huth; Yurii S Aulchenko; Gudmar Thorleifsson; Laura J McCulloch; Teresa Ferreira; Harald Grallert; Najaf Amin; Guanming Wu; Cristen J Willer; Soumya Raychaudhuri; Steve A McCarroll; Claudia Langenberg; Oliver M Hofmann; Josée Dupuis; Lu Qi; Ayellet V Segrè; Mandy van Hoek; Pau Navarro; Kristin Ardlie; Beverley Balkau; Rafn Benediktsson; Amanda J Bennett; Roza Blagieva; Eric Boerwinkle; Lori L Bonnycastle; Kristina Bengtsson Boström; Bert Bravenboer; Suzannah Bumpstead; Noisël P Burtt; Guillaume Charpentier; Peter S Chines; Marilyn Cornelis; David J Couper; Gabe Crawford; Alex S F Doney; Katherine S Elliott; Amanda L Elliott; Michael R Erdos; Caroline S Fox; Christopher S Franklin; Martha Ganser; Torben Jørgensen; Rob M van Dam; MAGIC investigators

doi:10.1038/ng.609

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira, Harald Grallert, Najaf Amin, Guanming Wu, Cristen J Willer, Soumya Raychaudhuri, Steve A McCarroll, Claudia Langenberg, Oliver M HofmannJosée Dupuis, Lu Qi, Ayellet V Segrè, Mandy van Hoek, Pau Navarro, Kristin Ardlie, Beverley Balkau, Rafn Benediktsson, Amanda J Bennett, Roza Blagieva, Eric Boerwinkle, Lori L Bonnycastle, Kristina Bengtsson Boström, Bert Bravenboer, Suzannah Bumpstead, Noisël P Burtt, Guillaume Charpentier, Peter S Chines, Marilyn Cornelis, David J Couper, Gabe Crawford, Alex S F Doney, Katherine S Elliott, Amanda L Elliott, Michael R Erdos, Caroline S Fox, Christopher S Franklin, Martha Ganser, Torben Jørgensen, Rob M van Dam, MAGIC investigators

1533 Citationer (Scopus)

Abstract

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	42
Udgave nummer	7
Sider (fra-til)	579-89
Antal sider	11
ISSN	1061-4036
DOI	https://doi.org/10.1038/ng.609
Status	Udgivet - 1 jul. 2010

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10.1038/ng.609

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Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., Aulchenko, Y. S., Thorleifsson, G., McCulloch, L. J., Ferreira, T., Grallert, H., Amin, N., Wu, G., Willer, C. J., Raychaudhuri, S., McCarroll, S. A., Langenberg, C., ... MAGIC investigators (2010). Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature Genetics, 42(7), 579-89. https://doi.org/10.1038/ng.609

Voight, BF, Scott, LJ, Steinthorsdottir, V, Morris, AP, Dina, C, Welch, RP, Zeggini, E, Huth, C, Aulchenko, YS, Thorleifsson, G, McCulloch, LJ, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, CJ, Raychaudhuri, S, McCarroll, SA, Langenberg, C, Hofmann, OM, Dupuis, J, Qi, L, Segrè, AV, van Hoek, M, Navarro, P, Ardlie, K, Balkau, B, Benediktsson, R, Bennett, AJ, Blagieva, R, Boerwinkle, E, Bonnycastle, LL, Bengtsson Boström, K, Bravenboer, B, Bumpstead, S, Burtt, NP, Charpentier, G, Chines, PS, Cornelis, M, Couper, DJ, Crawford, G, Doney, ASF, Elliott, KS, Elliott, AL, Erdos, MR, Fox, CS, Franklin, CS, Ganser, M, Jørgensen, T, van Dam, RM & MAGIC investigators 2010, 'Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis', Nature Genetics, bind 42, nr. 7, s. 579-89. https://doi.org/10.1038/ng.609

@article{f7c6a8782ed54db2afeff00bd0744d70,

title = "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis",

abstract = "By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P",

author = "Voight, {Benjamin F} and Scott, {Laura J} and Valgerdur Steinthorsdottir and Morris, {Andrew P} and Christian Dina and Welch, {Ryan P} and Eleftheria Zeggini and Cornelia Huth and Aulchenko, {Yurii S} and Gudmar Thorleifsson and McCulloch, {Laura J} and Teresa Ferreira and Harald Grallert and Najaf Amin and Guanming Wu and Willer, {Cristen J} and Soumya Raychaudhuri and McCarroll, {Steve A} and Claudia Langenberg and Hofmann, {Oliver M} and Jos{\'e}e Dupuis and Lu Qi and Segr{\`e}, {Ayellet V} and {van Hoek}, Mandy and Pau Navarro and Kristin Ardlie and Beverley Balkau and Rafn Benediktsson and Bennett, {Amanda J} and Roza Blagieva and Eric Boerwinkle and Bonnycastle, {Lori L} and {Bengtsson Bostr{\"o}m}, Kristina and Bert Bravenboer and Suzannah Bumpstead and Burtt, {Nois{\"e}l P} and Guillaume Charpentier and Chines, {Peter S} and Marilyn Cornelis and Couper, {David J} and Gabe Crawford and Doney, {Alex S F} and Elliott, {Katherine S} and Elliott, {Amanda L} and Erdos, {Michael R} and Fox, {Caroline S} and Franklin, {Christopher S} and Martha Ganser and Torben J{\o}rgensen and {van Dam}, {Rob M} and {MAGIC investigators}",

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T1 - Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

AU - Voight, Benjamin F

AU - Scott, Laura J

AU - Steinthorsdottir, Valgerdur

AU - Morris, Andrew P

AU - Dina, Christian

AU - Welch, Ryan P

AU - Zeggini, Eleftheria

AU - Huth, Cornelia

AU - Aulchenko, Yurii S

AU - Thorleifsson, Gudmar

AU - McCulloch, Laura J

AU - Ferreira, Teresa

AU - Grallert, Harald

AU - Amin, Najaf

AU - Wu, Guanming

AU - Willer, Cristen J

AU - Raychaudhuri, Soumya

AU - McCarroll, Steve A

AU - Langenberg, Claudia

AU - Hofmann, Oliver M

AU - Dupuis, Josée

AU - Qi, Lu

AU - Segrè, Ayellet V

AU - van Hoek, Mandy

AU - Navarro, Pau

AU - Ardlie, Kristin

AU - Balkau, Beverley

AU - Benediktsson, Rafn

AU - Bennett, Amanda J

AU - Blagieva, Roza

AU - Boerwinkle, Eric

AU - Bonnycastle, Lori L

AU - Bengtsson Boström, Kristina

AU - Bravenboer, Bert

AU - Bumpstead, Suzannah

AU - Burtt, Noisël P

AU - Charpentier, Guillaume

AU - Chines, Peter S

AU - Cornelis, Marilyn

AU - Couper, David J

AU - Crawford, Gabe

AU - Doney, Alex S F

AU - Elliott, Katherine S

AU - Elliott, Amanda L

AU - Erdos, Michael R

AU - Fox, Caroline S

AU - Franklin, Christopher S

AU - Ganser, Martha

AU - Jørgensen, Torben

AU - van Dam, Rob M

AU - MAGIC investigators

PY - 2010/7/1

Y1 - 2010/7/1

N2 - By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P

AB - By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P

U2 - 10.1038/ng.609

DO - 10.1038/ng.609

M3 - Journal article

C2 - 20581827

SN - 1061-4036

VL - 42

SP - 579

EP - 589

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Abstract

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