Tumour necrosis factor-alpha infusion produced insulin resistance but no change in the incretin effect in healthy volunteers

Signe Tellerup Nielsen, Louise Lehrskov-Schmidt, Rikke Krogh-Madsen, Thomas P J Solomon, Lars Lehrskov-Schmidt, Jens Juul Holst, Kirsten Møller

    22 Citationer (Scopus)

    Abstract

    Type 2 diabetes mellitus (T2DM) is associated with peripheral insulin resistance, impaired incretin effect, and increased plasma levels of tumour necrosis factor-alpha (TNF-α). Although TNF-α infusion at a dose that induces systemic inflammation in healthy volunteers has been demonstrated to induce peripheral insulin resistance, the influence of this cytokine on the incretin effect is unknown.
    OriginalsprogEngelsk
    TidsskriftDiabetes - Metabolism: Research and Reviews (Print Edition)
    Vol/bind29
    Udgave nummer8
    Sider (fra-til)655-63
    Antal sider9
    ISSN1520-7552
    DOI
    StatusUdgivet - nov. 2013

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