TY - JOUR
T1 - Tumors of the central nervous system among women treated with fertility drugs
T2 - a population-based cohort study
AU - Frandsen, Clarissa L B
AU - Jensen, Allan
AU - Poulsen, Frantz R
AU - Møller, Maria
AU - Lindquist, Sofie
AU - Albieri, Vanna
AU - Nøhr, Bugge
AU - Kjær, Susanne K
N1 - © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/10
Y1 - 2022/10
N2 - PURPOSE: To investigate the association between fertility drugs and tumors of the central nervous system (CNS).METHODS: This cohort study was based on The Danish Infertility Cohort and included 148,016 infertile women living in Denmark (1995-2017). The study cohort was linked to national registers to obtain information on use of specific fertility drugs, cancer diagnoses, covariates, emigration, and vital status. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all CNS tumors and separately for gliomas, meningiomas and diverse benign tumors of the brain and other parts of the CNS.RESULTS: During a median 11.3 years of follow-up, 328 women were diagnosed with CNS tumors. No marked associations were observed between use of the fertility drugs clomiphene citrate, gonadotropins, gonadotropin-releasing hormone receptor modulators and progesterone and CNS tumors. However, use of human chorionic gonadotropin was associated with a decreased rate of meningiomas (HR 0.49 95% CI 0.28-0.87). No clear associations with CNS tumors were observed according to time since first use or cumulative dose for any of the fertility drugs.CONCLUSION: No associations between use of most types of fertility drugs and CNS tumors were observed. However, our findings only apply to premenopausal women and additional studies with longer follow-up time are necessary.
AB - PURPOSE: To investigate the association between fertility drugs and tumors of the central nervous system (CNS).METHODS: This cohort study was based on The Danish Infertility Cohort and included 148,016 infertile women living in Denmark (1995-2017). The study cohort was linked to national registers to obtain information on use of specific fertility drugs, cancer diagnoses, covariates, emigration, and vital status. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all CNS tumors and separately for gliomas, meningiomas and diverse benign tumors of the brain and other parts of the CNS.RESULTS: During a median 11.3 years of follow-up, 328 women were diagnosed with CNS tumors. No marked associations were observed between use of the fertility drugs clomiphene citrate, gonadotropins, gonadotropin-releasing hormone receptor modulators and progesterone and CNS tumors. However, use of human chorionic gonadotropin was associated with a decreased rate of meningiomas (HR 0.49 95% CI 0.28-0.87). No clear associations with CNS tumors were observed according to time since first use or cumulative dose for any of the fertility drugs.CONCLUSION: No associations between use of most types of fertility drugs and CNS tumors were observed. However, our findings only apply to premenopausal women and additional studies with longer follow-up time are necessary.
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Female
KW - Fertility Agents/therapeutic use
KW - Humans
KW - Infertility, Female/drug therapy
KW - Meningeal Neoplasms
KW - Meningioma
KW - Risk Factors
UR - http://www.scopus.com/inward/record.url?scp=85137062886&partnerID=8YFLogxK
U2 - 10.1007/s10552-022-01610-w
DO - 10.1007/s10552-022-01610-w
M3 - Journal article
C2 - 35895242
SN - 0957-5243
VL - 33
SP - 1285
EP - 1293
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 10
ER -