TY - JOUR
T1 - Tumor interstitial fluid - a treasure trove of cancer biomarkers
AU - Gromov, Pavel
AU - Gromova, Irina
AU - Olsen, Charlotta Johanne
AU - Wielenga, V T
AU - Talman, Maj-Lis
AU - Serizawa, Reza R
AU - Moreira, José Manuel Alfonso
N1 - Copyright © 2013 Elsevier B.V. All rights reserved.
PY - 2013/11
Y1 - 2013/11
N2 - Tumor interstitial fluid (TIF) is a proximal fluid that, in addition to the set of blood soluble phase-borne proteins, holds a subset of aberrantly externalized components, mainly proteins, released by tumor cells and tumor microenvironment through various mechanisms, which include classical secretion, non-classical secretion, secretion via exosomes and membrane protein shedding. Consequently, the interstitial aqueous phase of solid tumors is a highly promising resource for the discovery of molecules associated with pathological changes in tissues. Firstly, it allows one to delve deeper into the regulatory mechanisms and functions of secretion-related processes in tumor development. Secondly, the anomalous secretion of molecules that is innate to tumors and the tumor microenvironment, being associated with cancer progression, offers a valuable source for biomarker discovery and possible targets for therapeutic intervention. Here we provide an overview of the features of tumor-associated interstitial fluids, based on recent and updated information obtained mainly from our studies of breast cancer. Data from the study of interstitial fluids recovered from several other types of cancer are also discussed. This article is a part of a Special Issue entitled: The Updated Secretome.
AB - Tumor interstitial fluid (TIF) is a proximal fluid that, in addition to the set of blood soluble phase-borne proteins, holds a subset of aberrantly externalized components, mainly proteins, released by tumor cells and tumor microenvironment through various mechanisms, which include classical secretion, non-classical secretion, secretion via exosomes and membrane protein shedding. Consequently, the interstitial aqueous phase of solid tumors is a highly promising resource for the discovery of molecules associated with pathological changes in tissues. Firstly, it allows one to delve deeper into the regulatory mechanisms and functions of secretion-related processes in tumor development. Secondly, the anomalous secretion of molecules that is innate to tumors and the tumor microenvironment, being associated with cancer progression, offers a valuable source for biomarker discovery and possible targets for therapeutic intervention. Here we provide an overview of the features of tumor-associated interstitial fluids, based on recent and updated information obtained mainly from our studies of breast cancer. Data from the study of interstitial fluids recovered from several other types of cancer are also discussed. This article is a part of a Special Issue entitled: The Updated Secretome.
KW - Animals
KW - Extracellular Fluid
KW - Humans
KW - Neoplasms
KW - Proteome
KW - Proteomics
KW - Tumor Markers, Biological
U2 - 10.1016/j.bbapap.2013.01.013
DO - 10.1016/j.bbapap.2013.01.013
M3 - Journal article
C2 - 23416532
VL - 1834
SP - 2259
EP - 2270
JO - Biochimica et Biophysica Acta
JF - Biochimica et Biophysica Acta
SN - 0006-3002
IS - 11
ER -