TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms

Keyphrases

• Hedgehog Signaling 100%
• TSC1 100%
• Tuberous Sclerosis Complex 100%
• Cilia Length 100%
• Mouse Embryonic Fibroblasts 55%
• Cilia 33%
• GLI2 33%
• Primary Cilia 22%
• Mammalian Target of Rapamycin (mTOR) 22%
• Transforming Growth Factor-β 22%
• Rapamycin 22%
• Autophagic Flux 22%
• Ciliary Length Control 22%
• Protein Synthesis 11%
• Transcription Factor 11%
• Phosphorylation 11%
• Reduced Expression 11%
• Growth Factor Signaling 11%
• Signaling Effectors 11%
• Negatively Regulate 11%
• Cellular Signaling 11%
• Smad2 11%
• Gli1 11%
• Hedgehog 11%
• Wnt5a 11%
• Control Signal 11%
• Exogenous Expression 11%
• Cilium Assembly 11%
• Cellular Signaling Pathways 11%
• MTOR Signaling 11%
• Complex Protein 11%

Biochemistry, Genetics and Molecular Biology

• Cilium 100%
• Hedgehog Signaling Pathway 100%
• TSC1 100%
• TSC2 100%
• Fibroblast 62%
• Signal Transduction 37%
• Mammalian Target of Rapamycin 25%
• Cancer Growth Factor 25%
• Protein Biosynthesis 12%
• Hedgehog 12%
• Transcription Factors 12%
• Synapsin I 12%
• Tuberous Sclerosis 12%
• mTOR Signaling 12%
• GLI2 12%
• Growth Factor Signaling 12%
• phosphorylation 12%