Abstract
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathic disease. TTP is due to reduced activity of the von Willebrand factor which cleaves ADAMTS13. The disease is characterized by thrombocytopenia (<20 billion/l) intravascular Coombs-negative haemolysis and schistocytes in blood smears. Determination of the ADAMTS13-activity is now becoming available as a routine analysis. We present two cases that illustrate the multi-facetted clinical presentation under which TTP occurs. The importance of access to ADAMTS13 measurements is stressed.
| Bidragets oversatte titel | Multi-facetted clinical presentation of thrombotic thrombocytopenic purpura |
|---|---|
| Originalsprog | Dansk |
| Tidsskrift | Ugeskrift for Laeger |
| Vol/bind | 171 |
| Udgave nummer | 5 |
| Sider (fra-til) | 340-2 |
| Antal sider | 3 |
| ISSN | 0041-5782 |
| Status | Udgivet - 26 jan. 2009 |
| Udgivet eksternt | Ja |
Emneord
- ADAM Proteins/blood
- ADAMTS13 Protein
- Adult
- Antibodies, Monoclonal/administration & dosage
- Antibodies, Monoclonal, Murine-Derived
- Dexamethasone/administration & dosage
- Female
- Humans
- Immunoglobulins, Intravenous/administration & dosage
- Plasmapheresis
- Pregnancy
- Pregnancy Complications, Cardiovascular/blood
- Purpura, Thrombotic Thrombocytopenic/blood
- Rituximab