Triterpene Acids from Rose Hip Powder Inhibit Self-antigen- and LPS-induced Cytokine Production and CD4(+) T-cell Proliferation in Human Mononuclear Cell Cultures

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    Abstract

    A triterpene acid mixture consisting of oleanolic, ursolic and betulinic acid isolated from a standardized rose hip powder (Rosa canina L.) has been shown to inhibit interleukin (IL)-6 release from Mono Mac 6 cells. The present study examined the effects of the triterpene acid mixture on the cytokine production and proliferation of CD4(+) T cells and CD19(+) B cells induced by a self-antigen, human thyroglobulin and by lipopolysaccharide in cultures of normal mononuclear cells. The triterpene acid mixture inhibited the production of tumor necrosis factor-α and IL-6 with estimated IC(50) values in the range 35-56 µg/mL, the Th1 cytokines interferon-γ and IL-2 (IC(50) values 10-20 µg/mL) and the antiinflammatory cytokine IL-10 (IC(50) values 18-21 µg/mL). Moreover, the mixture also inhibited CD4(+) T-cell and CD19(+) B-cell proliferation (IC(50) value 22 and 12 µg/mL, respectively). Together, these data demonstrate that oleanolic, ursolic and betulinic acid are active immunomodulatory constituents of the standardized rose hip powder. However, since the estimated IC(50) values are in the µg/mL range, it is questionable whether the content of the triterpene acids in the standardized rose hip powder, alone, can explain the reported clinical effects. Copyright © 2011 John Wiley & Sons, Ltd.
    OriginalsprogEngelsk
    TidsskriftPhytotherapy Research
    Vol/bind26
    Udgave nummer8
    Sider (fra-til)1142-1147
    ISSN0951-418X
    DOI
    StatusUdgivet - 2012

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