@article{2392d99cc640490bb97574826565c255,
title = "Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses",
abstract = "To evaluate meta-analyses with trial sequential analysis (TSA). TSA adjusts for random error risk and provides the required number of participants (information size) in a meta-analysis. Meta-analyses not reaching information size are analyzed with trial sequential monitoring boundaries analogous to interim monitoring boundaries in a single trial.",
keywords = "Data Interpretation, Statistical, False Positive Reactions, Humans, Infant, Newborn, Meta-Analysis as Topic, Randomized Controlled Trials as Topic, Research Design, Review Literature as Topic, Sample Size",
author = "Jesper Brok and Kristian Thorlund and Christian Gluud and J{\o}rn Wetterslev",
year = "2008",
month = aug,
doi = "10.1016/j.jclinepi.2007.10.007",
language = "English",
volume = "61",
pages = "763--9",
journal = "Journal of Clinical Epidemiology",
issn = "0895-4356",
publisher = "Elsevier Inc",
number = "8",
}