Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study

Dominique Castagliola; Bruno Ledergerber; Carlo Torti; Ard van Sighem; Daniel Podzamczer; Amanda Mocroft; Maria Dorrucci; Bernard Masquelier; Andrea de Luca; Klaus Jansen; Stephane De Wit; Niels Obel; Gerd Fätkenheuer; Giota Touloumi; Cristina Mussini; Antonella Castagna; Cristoph Stephan; Frederico Garcia; Robert Zangerle; Xavier Duval; Santiago Pérez-Hoyos; Laurence Meyer; Jade Ghosn; Céline Fabre-Colin; Jesper Kjaer; Genevieve Chene; Céline Fabre-Colin; Jesper Kjaer; Dominque Costagliola; Rebecca Lodwick; Bruno Ledergerber; Andrew Phillips; Pursuing Later Treatment Option II (PLATO II) project team

doi:10.1016/S1473-3099(11)70248-1

Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study

Dominique Castagliola, Bruno Ledergerber, Carlo Torti, Ard van Sighem, Daniel Podzamczer, Amanda Mocroft, Maria Dorrucci, Bernard Masquelier, Andrea de Luca, Klaus Jansen, Stephane De Wit, Niels Obel, Gerd Fätkenheuer, Giota Touloumi, Cristina Mussini, Antonella Castagna, Cristoph Stephan, Frederico Garcia, Robert Zangerle, Xavier DuvalSantiago Pérez-Hoyos, Laurence Meyer, Jade Ghosn, Céline Fabre-Colin, Jesper Kjaer, Genevieve Chene, Céline Fabre-Colin, Jesper Kjaer, Dominque Costagliola, Rebecca Lodwick, Bruno Ledergerber, Andrew Phillips, Pursuing Later Treatment Option II (PLATO II) project team

41 Citationer (Scopus)

Abstract

Limited treatment options have been available for people with HIV who have had virological failure of the three original classes of HIV antiretroviral drugs-so-called triple-class virological failure (TCVF). However, introduction of new drugs and drug classes might have improved outcomes. We aimed to assess trends in virological and clinical outcomes for individuals with TCVF in 2000-09.

Originalsprog	Engelsk
Tidsskrift	Lancet Infectious Diseases
Vol/bind	12
Udgave nummer	2
Sider (fra-til)	119-27
Antal sider	9
ISSN	1473-3099
DOI	https://doi.org/10.1016/S1473-3099(11)70248-1
Status	Udgivet - 2012

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10.1016/S1473-3099(11)70248-1

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Castagliola, D., Ledergerber, B., Torti, C., van Sighem, A., Podzamczer, D., Mocroft, A., Dorrucci, M., Masquelier, B., de Luca, A., Jansen, K., De Wit, S., Obel, N., Fätkenheuer, G., Touloumi, G., Mussini, C., Castagna, A., Stephan, C., Garcia, F., Zangerle, R., ... Pursuing Later Treatment Option II (PLATO II) project team (2012). Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study. Lancet Infectious Diseases, 12(2), 119-27. https://doi.org/10.1016/S1473-3099(11)70248-1

Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study. / Castagliola, Dominique; Ledergerber, Bruno; Torti, Carlo et al.
I: Lancet Infectious Diseases, Bind 12, Nr. 2, 2012, s. 119-27.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Castagliola, D, Ledergerber, B, Torti, C, van Sighem, A, Podzamczer, D, Mocroft, A, Dorrucci, M, Masquelier, B, de Luca, A, Jansen, K, De Wit, S, Obel, N, Fätkenheuer, G, Touloumi, G, Mussini, C, Castagna, A, Stephan, C, Garcia, F, Zangerle, R, Duval, X, Pérez-Hoyos, S, Meyer, L, Ghosn, J, Fabre-Colin, C, Kjaer, J, Chene, G, Fabre-Colin, C, Kjaer, J, Costagliola, D, Lodwick, R, Ledergerber, B, Phillips, A & Pursuing Later Treatment Option II (PLATO II) project team 2012, 'Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study', Lancet Infectious Diseases, bind 12, nr. 2, s. 119-27. https://doi.org/10.1016/S1473-3099(11)70248-1

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abstract = "Limited treatment options have been available for people with HIV who have had virological failure of the three original classes of HIV antiretroviral drugs-so-called triple-class virological failure (TCVF). However, introduction of new drugs and drug classes might have improved outcomes. We aimed to assess trends in virological and clinical outcomes for individuals with TCVF in 2000-09.",

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AU - Ledergerber, Bruno

AU - Torti, Carlo

AU - van Sighem, Ard

AU - Podzamczer, Daniel

AU - Mocroft, Amanda

AU - Dorrucci, Maria

AU - Masquelier, Bernard

AU - de Luca, Andrea

AU - Jansen, Klaus

AU - De Wit, Stephane

AU - Obel, Niels

AU - Fätkenheuer, Gerd

AU - Touloumi, Giota

AU - Mussini, Cristina

AU - Castagna, Antonella

AU - Stephan, Cristoph

AU - Garcia, Frederico

AU - Zangerle, Robert

AU - Duval, Xavier

AU - Pérez-Hoyos, Santiago

AU - Meyer, Laurence

AU - Ghosn, Jade

AU - Fabre-Colin, Céline

AU - Kjaer, Jesper

AU - Chene, Genevieve

AU - Fabre-Colin, Céline

AU - Kjaer, Jesper

AU - Costagliola, Dominque

AU - Lodwick, Rebecca

AU - Ledergerber, Bruno

AU - Phillips, Andrew

AU - Pursuing Later Treatment Option II (PLATO II) project team

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AB - Limited treatment options have been available for people with HIV who have had virological failure of the three original classes of HIV antiretroviral drugs-so-called triple-class virological failure (TCVF). However, introduction of new drugs and drug classes might have improved outcomes. We aimed to assess trends in virological and clinical outcomes for individuals with TCVF in 2000-09.

KW - Adolescent

KW - Adult

KW - Anti-HIV Agents

KW - CD4 Lymphocyte Count

KW - Cohort Studies

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Middle Aged

KW - RNA, Viral

KW - Regression Analysis

KW - Retrospective Studies

KW - Young Adult

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DO - 10.1016/S1473-3099(11)70248-1

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SN - 1473-3099

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ER -

Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study

Abstract

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